ID A0A1H8EAD4_9BACI Unreviewed; 739 AA.
AC A0A1H8EAD4;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Putative drug exporter of the RND superfamily {ECO:0000313|EMBL:SEN16479.1};
GN ORFNames=SAMN05192533_109224 {ECO:0000313|EMBL:SEN16479.1};
OS Mesobacillus persicus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Mesobacillus.
OX NCBI_TaxID=930146 {ECO:0000313|EMBL:SEN16479.1, ECO:0000313|Proteomes:UP000198553};
RN [1] {ECO:0000313|Proteomes:UP000198553}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B48,IBRC-M 10115,DSM 25386,CECT 8001
RC {ECO:0000313|Proteomes:UP000198553};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; FOBW01000009; SEN16479.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8EAD4; -.
DR STRING; 930146.SAMN05192533_109224; -.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000198553; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198553};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 198..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 689..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 223..353
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 626..716
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 739 AA; 80992 MW; 07DE577C2E64DEB1 CRC64;
MSLKKLVESV VGPKSRWLTL VIWVLIVGLL SFMWPQVNSE ETNSSQLLPD SAMSVEAERI
AEEQFPNETG VPLLVVWYRD GGLNEGDFKH VQAFYQDLKE KPLDYQSMVP DFGSMPLEVL
LQVASEDGEA LSTPIFYNTE ASVDELQESL DLLNEKINTL VGDEAFSKEL SDDGLHVRFT
GPIAIQTDAT ALFSQADVTL LIATVVLVLF LLIILYRSII LALVPLIGVG FAYGLISPLL
GYLASNGWIV VDAQAISIMT VLLFGAGTDY CLFLVSRYRD ELQLEPNKYK ALHLAIANSG
GAIMMSALTT ALGLLTLSLA QYASYNRFAV PFSVAIIIMG IAVLTLLPAI LAILGRVAFF
PFIPRTESMY QELEAKRGKP VRRPNYRSAF SRTAGRIVTS KPWFIIIITV IFLGVLAAFV
PKIDYTYGVF ESFPEDMPSR EGNTIIAEHY PVGEIAPVQL LIDTDGHDVS IEELLSTLPY
VEKVSEPLVG ERNANIKEYS VVLSINPYSN EAIVAIPELK SQAEAVLKDA GVVQAEARVW
LGGETATLYD TEQITSRDQN IIIPVVLGIM AILLVVYLRS IPAMLYLLLT VGLSFLSALG
LGWLVIHYGY GAEAMQGLIP LYAFVFLVAL GGDYNIFMIS SIWKNRKKMP LKKAISEGVE
ETSSVITSAG LILAGTFAVL AVLPLQVLVQ FGTVTAIGVL LDTFIVRPLL VPAITTALGR
FSFWPGELWK KKDGEKEEA
//
