ID A0A1H8HD14_9BURK Unreviewed; 343 AA.
AC A0A1H8HD14;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=D-lactate dehydrogenase {ECO:0000313|EMBL:SEN54162.1};
GN ORFNames=SAMN05428959_102316 {ECO:0000313|EMBL:SEN54162.1};
OS Duganella sp. CF517.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Telluria group; Duganella.
OX NCBI_TaxID=1881038 {ECO:0000313|EMBL:SEN54162.1, ECO:0000313|Proteomes:UP000198691};
RN [1] {ECO:0000313|Proteomes:UP000198691}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF517 {ECO:0000313|Proteomes:UP000198691};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; FODC01000002; SEN54162.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8HD14; -.
DR STRING; 1881038.SAMN05428959_102316; -.
DR OrthoDB; 9805416at2; -.
DR Proteomes; UP000198691; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12183; LDH_like_2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43026; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR PANTHER; PTHR43026:SF1; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000198691}.
FT DOMAIN 4..335
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 117..305
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 343 AA; 36752 MW; 151ABBE563633373 CRC64;
MKIAVYSAQP YDRRFLDEAR LDALAATPAS PIDAVYFDNR LTIDTVPLAH GCAVVCVFVN
DILDAEVLDA LHALGVRAVL LRCAGFNNVD VQAGERLGMF MARVPTYAPE AVAEHALALV
MTLNRRTHRA YARVREGNFA LDGLLGMTLH GKTVGIIGAG QIGTAAAQIF KGIGCTVLVS
DPAPQLQLQL GAIAARVTLE QLLAQSDIVS LHCPLMEATR HLINADSLAL MKPGAMLVNT
SRGALIDTMA VIAALKSKQL GALAIDVYEQ ESDLFFHDHS SDIIDDDVFQ RLMTFPNVLV
TGHQGFFTIE AMREIAAVTF ANLAAYMRGE PTANALGTGA RPT
//
