ID A0A1H8HQM2_9ACTN Unreviewed; 1135 AA.
AC A0A1H8HQM2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Zn-dependent metalloprotease {ECO:0000313|EMBL:SEN58580.1};
GN ORFNames=SAMN05660976_07868 {ECO:0000313|EMBL:SEN58580.1};
OS Nonomuraea pusilla.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=46177 {ECO:0000313|EMBL:SEN58580.1, ECO:0000313|Proteomes:UP000198953};
RN [1] {ECO:0000313|EMBL:SEN58580.1, ECO:0000313|Proteomes:UP000198953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43357 {ECO:0000313|EMBL:SEN58580.1,
RC ECO:0000313|Proteomes:UP000198953};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28A subfamily.
CC {ECO:0000256|ARBA:ARBA00005957}.
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388}.
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DR EMBL; FOBF01000030; SEN58580.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8HQM2; -.
DR STRING; 46177.SAMN05660976_07868; -.
DR Proteomes; UP000198953; Unassembled WGS sequence.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03876; M28_SGAP_like; 1.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR041756; M28_SGAP-like.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000313|EMBL:SEN58580.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SEN58580.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198953};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1135
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011531234"
FT DOMAIN 1017..1135
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT ACT_SITE 336
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT ACT_SITE 422
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ SEQUENCE 1135 AA; 116049 MW; C45601858C15F656 CRC64;
MKRLLAAAVG VATAASMALL ASPANAAPPG AAKDQDSASA RAAADPASLA AAVADRAVAS
GLDELSRGPD ESYRRVGVTP GASDMYFVSY ERTYKGLPVV GGDAVVVTDA AGHVRDTVAA
TGATTADVDT SPKISAEKAT EVARSKLSRV DDTAEPRLVV LAWGGKQRLA WEATVSGLAD
GKPSIQHVFV DARTGKVADS YDLVRAGTGN GYYYGQVTIA TSGSGSSYSM TDSTRPGIQC
GGQNGSAYTG TDDAWGNASG TNLETACVDA LYSVQREWDM LRDWLGRNGI NGSGRGFPAR
VGLADVNAYW NGSYTNFGHS QDNARQATPI DVVAHEFGHA IFQTTPGGAG SGNENGGLNE
ATGDIFGALT EHYANNPNDP PDYLVGEEVD LVGDGPIRNM YNPSALGDPN CYSSSIPNTE
VHSAAGPLNH WFYLLAEGSN PGGGKPSSPI CSGGPSSVTG VGVQNAGKIF MGALNRKTST
WRYANVRAAS VAAAIELFGA NSAECNTTKA AWSAISVAAA SGEPACGTST SDFSLTLNPT
SGSATPGGQA TVTVNTQTTS GSAQTVALSA PNLPSGITAA FNPASVTSGG SSTLTLSVGS
SVAQGSYQIT VTGTGSTSHS ATFGLTVGQG PGGTEPPDVS LSNIKGHLTQ LQSIATSNGG
NRRSTTNGYL QSVQYVEDKL KAAGYTVTRQ SCTSGCTSGA GPNLIADWPG GDANQVIMSG
AHLDSVSAGP GINDNGSGSA TLLEVALTLA SKNPTLAKHV RFGWWTDEEQ GLNGSEFYVN
SLSSTDRSKI KVYYNYDMVG SPNGGYFINN ISTTAAQYLK EFYDKLNLQP EENTEGANRS
DDASFRNAGI ASSGVAAGAS YTKTSAQASK WGGTAGRAYD SCYHSSCDTT TNINDTILDR
AADAAMYAVW KQSVGTGTPT RDFSVSTNPG SGTVQAGAQA TTTVGTTTTA GTAQTVNLSA
SGLPTGASAA FNPQSVTSGG SSTLTISTSA TTPAGSYTVT VTGTGETGAR TATYALTVQG
TSGGRTFTND TDVQIADWAN VQSTITSTAS GAAASPVKLS ITINHTCAED LDIWLRGPDG
TWYAVDRYGG TTCTQYGTRT FSVPVSQQAS GQWVLDIEDV YLGDTGTLDS WSITV
//
