ID   A0A1H8J2Q6_9RHOB        Unreviewed;       305 AA.
AC   A0A1H8J2Q6;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=inorganic diphosphatase {ECO:0000256|ARBA:ARBA00012146};
DE            EC=3.6.1.1 {ECO:0000256|ARBA:ARBA00012146};
DE   AltName: Full=Pyrophosphate phospho-hydrolase {ECO:0000256|ARBA:ARBA00032535};
GN   ORFNames=SAMN04488103_107130 {ECO:0000313|EMBL:SEN75203.1};
OS   Gemmobacter aquatilis.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae; Gemmobacter.
OX   NCBI_TaxID=933059 {ECO:0000313|EMBL:SEN75203.1, ECO:0000313|Proteomes:UP000198761};
RN   [1] {ECO:0000313|EMBL:SEN75203.1, ECO:0000313|Proteomes:UP000198761}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 3857 {ECO:0000313|EMBL:SEN75203.1,
RC   ECO:0000313|Proteomes:UP000198761};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:43474; EC=3.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000926};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR   EMBL; FOCE01000007; SEN75203.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H8J2Q6; -.
DR   STRING; 933059.SAMN04488103_107130; -.
DR   OrthoDB; 9766150at2; -.
DR   Proteomes; UP000198761; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR   Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR   InterPro; IPR001667; DDH_dom.
DR   InterPro; IPR038763; DHH_sf.
DR   InterPro; IPR004097; DHHA2.
DR   InterPro; IPR038222; DHHA2_dom_sf.
DR   PANTHER; PTHR12112; BNIP - RELATED; 1.
DR   PANTHER; PTHR12112:SF22; MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE; 1.
DR   Pfam; PF01368; DHH; 1.
DR   Pfam; PF02833; DHHA2; 1.
DR   SMART; SM01131; DHHA2; 1.
DR   SUPFAM; SSF64182; DHH phosphoesterases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198761}.
FT   DOMAIN          180..305
FT                   /note="DHHA2"
FT                   /evidence="ECO:0000259|SMART:SM01131"
SQ   SEQUENCE   305 AA;  32526 MW;  F8CF0D87A10B8A27 CRC64;
     MIQVFGHKAP DTDSTGSPIV WAWYLTEVKG TPAKPVLLGE PNTEAAFVLR HWGLDKPEII
     ADIEPGAEVV VVDTNNPAEL PAGIHDAKLL AIIDHHMLVG GLKTKTPIDI TIRPLACTAT
     LMHDLMGADA ARAPRAIKGA MLSCILSDTL EFRSPTTTAH DRAVAEALAA DLGVTIAEFA
     AAMFAAKSDV SSFSDAELLR MDSKEYNVAG KELRVSVLET TAPQVLLDRK ASLMDSMVAV
     AKEDGADQVL LFVIDILNEE ATLLVPNDLV KQLAEASFGC TVTGDTVVLP GVMSRKKQII
     PSLKL
//