ID A0A1H8JF05_9BURK Unreviewed; 692 AA.
AC A0A1H8JF05;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=SAMN02745977_02049 {ECO:0000313|EMBL:SEN78886.1};
OS Brachymonas denitrificans DSM 15123.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Brachymonas.
OX NCBI_TaxID=1121117 {ECO:0000313|EMBL:SEN78886.1, ECO:0000313|Proteomes:UP000199531};
RN [1] {ECO:0000313|EMBL:SEN78886.1, ECO:0000313|Proteomes:UP000199531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15123 {ECO:0000313|EMBL:SEN78886.1,
RC ECO:0000313|Proteomes:UP000199531};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; FOCW01000006; SEN78886.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8JF05; -.
DR STRING; 1121117.SAMN02745977_02049; -.
DR OrthoDB; 5441773at2; -.
DR Proteomes; UP000199531; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF68; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000199531}.
FT DOMAIN 232..510
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 253..260
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 692 AA; 76920 MW; A4F7692D39855676 CRC64;
MEFRIADTFT TSLARLTGDE QKAAKTTAFD LQMDPAGKGM SFHKLDRAKD PNFWSVRVSR
DIRLIVHKTA GSLLLCYVDH HDKAYQWAER RKLEVHPTTG AAQLVEVRER VEEILVPKYV
EDSRPATQQK PKLFAKYADA QLLAYGVPQD WLADVKAADE DSLLELADHL PGEAAEALLE
LATGGTPTLP EVAGKGADPF LHPDAQRRFR VMSDMDELAR ALEYPWDKWT VFLHPAQRQL
VERHYNGAAR VSGSAGTGKT VVALHRAVHL AHQDEDARVL LSTFSDTLAN ALRGNLYRLI
WNTPRLGERI DVAAMDALGI RLYAAEFGKP VFASRDEIST LLKAAATQVD GLKASAAFLL
SEWEDVVDTW QVESWEAYRD AKRLGRKTRL SEAQRALYWQ VFAKVKAQLK QAGKITAAEM
FAKLAEAMPK RKHPVFDYIV VDEAQDIGVQ QLRFLAAIAG NRANALFFAG DLGQRIFQTP
FSWKSLGVDV RGRSRTLNIN YRTSHQIRSQ ADRLLGPEVS DVDGNVESRK GTISVFNGPE
PTICSYADAE AESQAVGVWL QQCNTSGVLP QEIGVFVRSD SELSRAQTAV KAAGLQGRVL
GKDMATEEGF VSITTMHLAK GMEFRVVAVM ACDDEIIPSQ VRIDTAADEA ELTEIYNTER
QLLYVACTRA RDQLHVSAVK PESEFLEDLL QK
//
