ID A0A1H8KU22_9FIRM Unreviewed; 472 AA.
AC A0A1H8KU22;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Na+/H+ antiporter NhaC {ECO:0000313|EMBL:SEN95898.1};
GN ORFNames=SAMN05216454_1424 {ECO:0000313|EMBL:SEN95898.1};
OS Peptostreptococcus russellii.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Peptostreptococcus.
OX NCBI_TaxID=215200 {ECO:0000313|EMBL:SEN95898.1, ECO:0000313|Proteomes:UP000199512};
RN [1] {ECO:0000313|EMBL:SEN95898.1, ECO:0000313|Proteomes:UP000199512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Calf135 {ECO:0000313|EMBL:SEN95898.1,
RC ECO:0000313|Proteomes:UP000199512};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000256|ARBA:ARBA00038435}.
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DR EMBL; FODF01000042; SEN95898.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8KU22; -.
DR OrthoDB; 9790605at2; -.
DR Proteomes; UP000199512; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR PANTHER; PTHR33451:SF4; NA+_H+ ANTIPORTER-RELATED; 1.
DR Pfam; PF03553; Na_H_antiporter; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199512};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..233
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
FT DOMAIN 256..443
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 472 AA; 50675 MW; D0B142F704E1D484 CRC64;
MKDIKFENER AEKISKDELE IAPNGKALIP FLVFIGVYLG SGIILQLKGV EMAFYQFPAP
LAVVIGIIAA FLIIKGKFSD KFDTFIKGCG DSNIIIMCII YLLAGGFASV CKAMGGIDST
VNLGLTYIPP QYLAAGVFVI SAFIATATGT SVGSAAAVGP IAIAVAEKSG TSLPLMMGCV
LGGIMLGDNL SIISDTTIAS TRTQGCDMKD KFKLNLWLTV LPAIITIVLL ILFAKPDTVV
STGDHQFNII KVLPYIFVLV TAIFGMNVFM VLIGGTIFAG AIGIYFGDLN LLTLFQSIYS
GFTGMTDIFL LSLLTGGLAE MVNKAGGISY LLVNIQKFIK GKKTAQLGIS ALVSITDIAV
ANNTVSIIIN GEIAKRICYK YKIDPRRSAA LLSTFSTVFQ GLIPYGAQML IVTSFSNGKV
SPLEVLPYTW FIYLLAISAI VSIFIPFSDG LIRKNPWNFD KEIDEKSLLE KN
//
