ID   A0A1H8R7H0_9ACTN        Unreviewed;       366 AA.
AC   A0A1H8R7H0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=O-methyltransferase {ECO:0000313|EMBL:SEO61863.1};
GN   ORFNames=SAMN05216267_10338 {ECO:0000313|EMBL:SEO61863.1};
OS   Actinacidiphila rubida.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Actinacidiphila.
OX   NCBI_TaxID=310780 {ECO:0000313|EMBL:SEO61863.1, ECO:0000313|Proteomes:UP000181951};
RN   [1] {ECO:0000313|EMBL:SEO61863.1, ECO:0000313|Proteomes:UP000181951}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.2026 {ECO:0000313|EMBL:SEO61863.1,
RC   ECO:0000313|Proteomes:UP000181951};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FODD01000033; SEO61863.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H8R7H0; -.
DR   STRING; 310780.SAMN05216267_10338; -.
DR   OrthoDB; 582216at2; -.
DR   Proteomes; UP000181951; Unassembled WGS sequence.
DR   GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR031725; ASMT_dimerisation.
DR   InterPro; IPR016461; COMT-like.
DR   InterPro; IPR001077; O_MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF16864; Dimerisation2; 1.
DR   Pfam; PF00891; Methyltransf_2; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51683; SAM_OMT_II; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:SEO61863.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000181951};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000313|EMBL:SEO61863.1}.
FT   DOMAIN          46..127
FT                   /note="Acetylserotonin O-methyltransferase dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16864"
FT   DOMAIN          201..349
FT                   /note="O-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00891"
SQ   SEQUENCE   366 AA;  38335 MW;  BC726A7177A20FF8 CRC64;
     MTTHPATTHP ASAHQTAVTD EGTAVPAGGA LFDAAPGGGV PDPDRVLRLI NGYWATGVLG
     AAASHRVFTH LAQGARDAAQ VAGRAGISER GAQTLLDGLV SVGLVRVEAG VYRNTAEAAT
     YLVEDSAVSL SAFAKLKLAH MGALTDLPQV VAAGGPITDA VVEVADNPHW QELVKAIAPQ
     SVPAARLATT VLGIEQAGPI TILDVGGGSG IYSAVWLAAN AQARAVQLDW QPINAIARRL
     MDERGLGDRF TCIDGDFHTT DFGSGGYDLA VYSHIAHQEG PQANTEVFTR LRRALKPGGA
     LLVCDYVVDD DRTGPGFPLI FASEMLLKSH QGSTWRAQDY RDWLTKAGFT DITLHSAPPA
     TLVVAR
//