ID   A0A1H8T3C3_9PSEU        Unreviewed;       317 AA.
AC   A0A1H8T3C3;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Carnitine 3-dehydrogenase {ECO:0000313|EMBL:SEO85447.1};
GN   ORFNames=SAMN04489732_102412 {ECO:0000313|EMBL:SEO85447.1};
OS   Amycolatopsis saalfeldensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=394193 {ECO:0000313|EMBL:SEO85447.1, ECO:0000313|Proteomes:UP000198582};
RN   [1] {ECO:0000313|EMBL:SEO85447.1, ECO:0000313|Proteomes:UP000198582}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44993 {ECO:0000313|EMBL:SEO85447.1,
RC   ECO:0000313|Proteomes:UP000198582};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FOEF01000002; SEO85447.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H8T3C3; -.
DR   STRING; 394193.SAMN04489732_102412; -.
DR   OrthoDB; 9771883at2; -.
DR   Proteomes; UP000198582; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000198582}.
FT   DOMAIN          12..187
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          191..268
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   317 AA;  33423 MW;  A5AE729DEA60C2ED CRC64;
     MPDVSAVDTI DTVACVGAGV IGGGWVAHFL ARGYRVRAWD PAPDAAAKLT RLVDAAWPAL
     TSLGLADGAS RDHLTVTATL AEAVEGAGFV QESAPEDLAL KQKLLADIDA VTPAGVVVAS
     STSGYGMTEM QVAAKTPERL VVGHPFNPPY LIPLVEVVGG KLTSPQAVEW AGAFYRHVGK
     TVITMADEVP GFIANRLQEA LWREALHMVA NGEATVEQID TAITDGPGLR WPVQGPMLTF
     HLAGGEGGMA HMLDHFGPSL KSPWTRLDAP ELTKKLRDAV VEGCEEEAGE RTIADLVAER
     DRAIIAIQEA VGSARRG
//