ID   A0A1H8WGS0_9ACTN        Unreviewed;       338 AA.
AC   A0A1H8WGS0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Pyruvate dehydrogenase E1 component alpha subunit {ECO:0000313|EMBL:SEP26799.1};
GN   ORFNames=SAMN05660991_04392 {ECO:0000313|EMBL:SEP26799.1};
OS   Trujillella endophytica.
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Trujillonella.
OX   NCBI_TaxID=673521 {ECO:0000313|EMBL:SEP26799.1, ECO:0000313|Proteomes:UP000198960};
RN   [1] {ECO:0000313|EMBL:SEP26799.1, ECO:0000313|Proteomes:UP000198960}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45413 {ECO:0000313|EMBL:SEP26799.1,
RC   ECO:0000313|Proteomes:UP000198960};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; FOEE01000020; SEP26799.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H8WGS0; -.
DR   STRING; 673521.SAMN05660991_04392; -.
DR   OrthoDB; 9766715at2; -.
DR   Proteomes; UP000198960; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:SEP26799.1}.
FT   DOMAIN          11..311
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   338 AA;  35766 MW;  48C7F3EB9CA9C110 CRC64;
     MDTDLQLDAL RRMVRIRRFE EAAMSIVRKG QGIAGSVHIC IGQEGAIVGS CLALRREDYM
     VGYHRSHGHP IAKGADMGPL MAELMGRATG VCRGKGGSMH LADFSVGSLG ETAIVGAGIP
     QAVGAAYSAR VRGTDQVALA FFGDGAANIG SFHEGLNLAA AWNLGVVFVC ENNLYAMSTA
     LADTMAADSI AARAAAYRMP GIEVDGQDVG AVHEAVSAAV ERGRAGGGPT LVEARTYRYR
     DHAEYGTLDL GHRAVEELEQ WRTRDPIDLL RARLLDSGVD VALLDQLDAD VAAEVAAAVT
     FAKRSPMPAP EELYEDLWAT PIEPSPRRDA VPVAGAAR
//