ID   A0A1H8XCC1_9PSEU        Unreviewed;       851 AA.
AC   A0A1H8XCC1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Formate dehydrogenase major subunit {ECO:0000313|EMBL:SEP37463.1};
GN   ORFNames=SAMN04489732_10714 {ECO:0000313|EMBL:SEP37463.1};
OS   Amycolatopsis saalfeldensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=394193 {ECO:0000313|EMBL:SEP37463.1, ECO:0000313|Proteomes:UP000198582};
RN   [1] {ECO:0000313|EMBL:SEP37463.1, ECO:0000313|Proteomes:UP000198582}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44993 {ECO:0000313|EMBL:SEP37463.1,
RC   ECO:0000313|Proteomes:UP000198582};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC       oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
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DR   EMBL; FOEF01000007; SEP37463.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H8XCC1; -.
DR   STRING; 394193.SAMN04489732_10714; -.
DR   Proteomes; UP000198582; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02792; MopB_CT_Formate-Dh-Na-like; 1.
DR   Gene3D; 2.40.40.20; -; 1.
DR   Gene3D; 3.40.50.740; -; 1.
DR   Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 2.
DR   InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR   InterPro; IPR048158; Formate_DH_Act.
DR   InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR   InterPro; IPR006656; Mopterin_OxRdtase.
DR   NCBIfam; NF041513; formate_DH_Act; 1.
DR   PANTHER; PTHR43598:SF1; FORMATE DEHYDROGENASE, NITRATE-INDUCIBLE, MAJOR SUBUNIT; 1.
DR   PANTHER; PTHR43598; TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT B; 1.
DR   Pfam; PF00384; Molybdopterin; 2.
DR   Pfam; PF01568; Molydop_binding; 1.
DR   SUPFAM; SSF50692; ADC-like; 1.
DR   SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00022485};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198582}.
FT   DOMAIN          3..390
FT                   /note="Molybdopterin oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00384"
FT   DOMAIN          420..461
FT                   /note="Molybdopterin oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00384"
FT   DOMAIN          699..816
FT                   /note="Molybdopterin dinucleotide-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01568"
FT   REGION          114..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   851 AA;  93337 MW;  4A62AE399B467846 CRC64;
     MAECHPVGFQ WVMEAKARGA KIIHVDPRFT RTSAVSHVHA ALRAGTDIAF LGGLINHVLR
     NGLDFREYVL AYTNAAAILT EEFADTEDLD GLFSGYDPEK RQYDISTWAY EDADATPAAG
     SGEPEQSGEH HHGGERHQRA ARGESYGSGG ASVHAKPKTD ETLQHPRCVY QVLKRHFARY
     TPEAVADICG LPVEQFAEIA EAVTANSGRE RTTAWVYSVG WTHHTVGAQY IRTASILQTL
     LGNIGRPGGG ILALRGHASI QGSTDIPTLF NLLPGYIPMP HAHEHFDLDG FVAADAGKTG
     FWGNMRAYTV SLLKAYWGES AQPGNDFRFD YLPRLTGDHG TYATVQQQIE GECKGYFLVG
     ENPAVGSANG KFQRLGLANL DWLVVRDLQL IESATFWKNG QEIETGELAT TEIGTEVFFL
     PAAAHTEKDG SFTNTQRLLQ WHHKAVEPPG EARSDLWFYY HLGRLIRERI GDDPRDAPLR
     DLTWSYPTAG PTADPSAESV LAEINGHGPD GPLAAYTELK DDGSTTCGCW IYCGVRADGH
     NHAADRKPGS EQDWVAGGWA WAWPANRRIL YNRASADPDG KAWSERKKLI TWDAGQGRWV
     GPDVPDFEVT KPPDYVPPEG AKAQAALGGA DAFIMQTDGK AWLFAPAGLA DGPLPAHYEP
     FESPVGNALY SQQESPTRQT LDSPHNRYNP ARSKAYPYVF TTYRLTEHHT AGGMSRTLPY
     LAELQPEFFC EVSPALAAER GLEHLGWATI VSARTAIEAR VLVTDRIKPL KVRGRTIHQV
     GLPYHWGPNG LSRGDAANDL LSVVMDPNVH IQEAKAATCD IRPGRRPRGP ALPVHVEEYR
     SRAEEGEPTD G
//