ID   A0A1H8Y820_9PROT        Unreviewed;       308 AA.
AC   A0A1H8Y820;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   SubName: Full=Pyruvate dehydrogenase E1 component alpha subunit {ECO:0000313|EMBL:SEP48206.1};
GN   ORFNames=SAMN02990966_06991 {ECO:0000313|EMBL:SEP48206.1};
OS   Rhodospirillales bacterium URHD0017.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales.
OX   NCBI_TaxID=1380357 {ECO:0000313|EMBL:SEP48206.1, ECO:0000313|Proteomes:UP000198826};
RN   [1] {ECO:0000313|EMBL:SEP48206.1, ECO:0000313|Proteomes:UP000198826}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=URHD0017 {ECO:0000313|EMBL:SEP48206.1,
RC   ECO:0000313|Proteomes:UP000198826};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; FODP01000025; SEP48206.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H8Y820; -.
DR   STRING; 1380357.SAMN02990966_06991; -.
DR   Proteomes; UP000198826; Unassembled WGS sequence.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:SEP48206.1}.
FT   DOMAIN          15..268
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   308 AA;  33472 MW;  FA098322E86EA2F7 CRC64;
     MKDEAIYRRL FRTALLIRLV EERIIELYPS DKIQSPVHLS IGQEAVAVGV CDGLKPDDLV
     FATYRSHGFY IAKGGSLDAM FAELYGRKGG VSGGKAGSMH LAAPEVGLMG SSAVVASTIP
     HAVGAALSFK RRGLSQIAVA VFGDGATEEG VYHESLNFAA LMKVPVLFLC EDNGLAVHSH
     RPVRQSYRLA EHAASFGIAS RRLEEGWDML AIRQATLEAA AKVRAGEPFV LEIVTSRYKE
     HVGVGEDFHF NYRTSDGVDA WKRRDPLIVD QKLVATLRPD IEREIEAAVA FAEASPAPGR
     DELLADVI
//