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Database: UniProt
Entry: A0A1H8YH10_9PSEU
LinkDB: A0A1H8YH10_9PSEU
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ID   A0A1H8YH10_9PSEU        Unreviewed;       963 AA.
AC   A0A1H8YH10;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Glycine dehydrogenase (decarboxylating) {ECO:0000256|HAMAP-Rule:MF_00711};
DE            EC=1.4.4.2 {ECO:0000256|HAMAP-Rule:MF_00711};
DE   AltName: Full=Glycine cleavage system P-protein {ECO:0000256|HAMAP-Rule:MF_00711};
DE   AltName: Full=Glycine decarboxylase {ECO:0000256|HAMAP-Rule:MF_00711};
DE   AltName: Full=Glycine dehydrogenase (aminomethyl-transferring) {ECO:0000256|HAMAP-Rule:MF_00711};
GN   Name=gcvP {ECO:0000256|HAMAP-Rule:MF_00711};
GN   ORFNames=SAMN04489732_11678 {ECO:0000313|EMBL:SEP51504.1};
OS   Amycolatopsis saalfeldensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=394193 {ECO:0000313|EMBL:SEP51504.1, ECO:0000313|Proteomes:UP000198582};
RN   [1] {ECO:0000313|EMBL:SEP51504.1, ECO:0000313|Proteomes:UP000198582}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44993 {ECO:0000313|EMBL:SEP51504.1,
RC   ECO:0000313|Proteomes:UP000198582};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The glycine cleavage system catalyzes the degradation of
CC       glycine. The P protein binds the alpha-amino group of glycine through
CC       its pyridoxal phosphate cofactor; CO(2) is released and the remaining
CC       methylamine moiety is then transferred to the lipoamide cofactor of the
CC       H protein. {ECO:0000256|ARBA:ARBA00003788, ECO:0000256|HAMAP-
CC       Rule:MF_00711}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage
CC         complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-
CC         L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304,
CC         Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099,
CC         ChEBI:CHEBI:83143; EC=1.4.4.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00033655, ECO:0000256|HAMAP-
CC         Rule:MF_00711};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|HAMAP-Rule:MF_00711, ECO:0000256|PIRSR:PIRSR603437-50};
CC   -!- SUBUNIT: The glycine cleavage system is composed of four proteins: P,
CC       T, L and H. {ECO:0000256|ARBA:ARBA00011690, ECO:0000256|HAMAP-
CC       Rule:MF_00711}.
CC   -!- SIMILARITY: Belongs to the GcvP family. {ECO:0000256|ARBA:ARBA00010756,
CC       ECO:0000256|HAMAP-Rule:MF_00711}.
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DR   EMBL; FOEF01000016; SEP51504.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H8YH10; -.
DR   STRING; 394193.SAMN04489732_11678; -.
DR   Proteomes; UP000198582; Unassembled WGS sequence.
DR   GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IEA:UniProtKB-UniRule.
DR   CDD; cd00613; GDC-P; 2.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 2.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 2.
DR   HAMAP; MF_00711; GcvP; 1.
DR   InterPro; IPR003437; GcvP.
DR   InterPro; IPR049316; GDC-P_C.
DR   InterPro; IPR049315; GDC-P_N.
DR   InterPro; IPR020581; GDC_P.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR00461; gcvP; 1.
DR   PANTHER; PTHR11773:SF1; GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11773; GLYCINE DEHYDROGENASE, DECARBOXYLATING; 1.
DR   Pfam; PF21478; GcvP2_C; 1.
DR   Pfam; PF02347; GDC-P; 2.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 2.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, ECO:0000256|HAMAP-
KW   Rule:MF_00711};
KW   Pyridoxal phosphate {ECO:0000256|HAMAP-Rule:MF_00711,
KW   ECO:0000256|PIRSR:PIRSR603437-50};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198582}.
FT   DOMAIN          29..454
FT                   /note="Glycine cleavage system P-protein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02347"
FT   DOMAIN          485..738
FT                   /note="Glycine cleavage system P-protein N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02347"
FT   DOMAIN          784..905
FT                   /note="Glycine dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21478"
FT   MOD_RES         711
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00711,
FT                   ECO:0000256|PIRSR:PIRSR603437-50"
SQ   SEQUENCE   963 AA;  102010 MW;  CC7FBFC98A736ABA CRC64;
     MTEGEFPVHR CARCPSRGAP ITSTPFDARH IGPAEAERAK MLAETGHGSL DSLVEAAVPS
     AIRATRDLDL PAAATEEEAT AELRALAALN RPMTQMIGLG YSDTVTPGVI RRNVLENPAW
     YTAYTPYQPE ISQGRLEALL NFQTMVADLT GLATANASLL DESTAVAEAM TLMRRASKAK
     SNVVVLDAEC LPQTIAVVRT RAAALGIDVQ VRDLLTGLPE EFFGMVVQYP GASGVLRGRG
     FYHAVSEAAK AAGALYTVAA DLLALTLITS PGEFGADVAA GSTQRFGVPL GYGGPHAGYM
     AVRAGLERSL PGRLVGVSVD ADGNSAYRLA LQTREQHIRR EKATSNICTA QVLPAVLAAM
     YAVYHGPDGL QAIANRVHGL AAGLADALRA GGVEVVHESF FDTVVAHVPG RAAEVHEAAR
     EAGINLGHVD ADHVRVACDE VTRPDTIAKV LRAFGVDAKW TVATALPNGI VRESGFMGHE
     VFSTHRSETA MLRYLRRLSD QDYALDRGMI PLGSCTMKLN ATTEMEPISW REFAGIHPFA
     PAEDAQGYHV LVEQLSGWLA EVTGYDRVSL QPNAGSQGEL AGLLAIRGYH HANGQPERDV
     CLIPSSAHGT NAASAVLAGM RVVVVKCTDE GNVDLADLQA KVDAHRETLA AIMVTYPSTH
     GVYEHGIERL AKIVHDGGGQ VYVDGANLNA LLGLAKPGEF GGDVSHLNLH KTFCIPHGGG
     GPGVGPVAVR AHLAPYLPNH PLLDQAGPAT GVGPISGAPY GSASILPISW AYVRMMGGPG
     LTTATKVAVL AANYVASRLS PHFPVLYTGQ DGLVAHECIL DLRGITKETG VTVDDVAKRL
     IDYGFHAPTM SFPVAGTLMV EPTESEDLGE IDRFIAAMIA IRGEIDQVAA GRWTAETSPL
     RGAPHTAEAL VGEWDADYDR ELAVYPAGVS RKNKYWPPVR RIDGARGDRN LVCSCPPLNA
     YEG
//
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