ID A0A1H8Z601_9ACTN Unreviewed; 395 AA.
AC A0A1H8Z601;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Acetyl-CoA acyltransferase {ECO:0000313|EMBL:SEP59816.1};
GN ORFNames=SAMN04487983_100163 {ECO:0000313|EMBL:SEP59816.1};
OS Streptomyces sp. yr375.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761906 {ECO:0000313|EMBL:SEP59816.1, ECO:0000313|Proteomes:UP000198568};
RN [1] {ECO:0000313|EMBL:SEP59816.1, ECO:0000313|Proteomes:UP000198568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR375 {ECO:0000313|EMBL:SEP59816.1,
RC ECO:0000313|Proteomes:UP000198568};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FOFF01000001; SEP59816.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8Z601; -.
DR STRING; 1761906.SAMN04487983_100163; -.
DR OrthoDB; 1402717at2; -.
DR Proteomes; UP000198568; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:SEP59816.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198568};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:SEP59816.1}.
FT DOMAIN 7..265
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 274..394
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 90
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 351
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 381
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 395 AA; 41326 MW; 92B5414382FDB138 CRC64;
MRPVHFAAAR RTPVGRLRGA LSGVRPDDLA AAVIRGLVAD VPALDPARVD DVYWGAANQA
GEDNRNVARM AALLAGLPES VPGATVNRLC ASGLEAVTMA ARTIAAGEAD IVLAGGSESM
SRAPFVLARP DEALPHRVET VDTRLGWRLV NPAMKDLHGL LAMGETAEEV AARHGVSRER
QDAFALRSHR LAALARKNGH FDDELLPVRR ADGVVVDADE GIREDTSPEK LASLKPVFRE
GGTVTAGNAS PMNDGAAGLL LVSEEVLDEL GLESLGRYVA GASAGVHPDV MGIGPVPATR
KALARAGWSV EDVQEAEFNE AFAAQVLACV DQLGIDPDRV NPSGGAIALG HPLGCSGARI
LTTLLHRMRR TGAHRALATM CVGVGQGSAV LVERR
//
