ID A0A1H8Z7M3_9RHOB Unreviewed; 183 AA.
AC A0A1H8Z7M3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Glutathione-dependent peroxiredoxin {ECO:0000256|RuleBase:RU366011};
DE EC=1.11.1.27 {ECO:0000256|RuleBase:RU366011};
GN ORFNames=SAMN04488092_101331 {ECO:0000313|EMBL:SEP60382.1};
OS Thalassovita taeanensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Thalassovita.
OX NCBI_TaxID=657014 {ECO:0000313|EMBL:SEP60382.1, ECO:0000313|Proteomes:UP000198634};
RN [1] {ECO:0000313|EMBL:SEP60382.1, ECO:0000313|Proteomes:UP000198634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22007 {ECO:0000313|EMBL:SEP60382.1,
RC ECO:0000313|Proteomes:UP000198634};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of
CC hydrogen peroxide and organic hydroperoxides to water and alcohols,
CC respectively. Plays a role in cell protection against oxidative stress
CC by detoxifying peroxides. {ECO:0000256|RuleBase:RU366011}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a hydroperoxide + 2 glutathione = an alcohol + glutathione
CC disulfide + H2O; Xref=Rhea:RHEA:62632, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:57925,
CC ChEBI:CHEBI:58297; EC=1.11.1.27;
CC Evidence={ECO:0000256|RuleBase:RU366011};
CC -!- SIMILARITY: Belongs to the peroxiredoxin family. Prx5 subfamily.
CC {ECO:0000256|RuleBase:RU366011}.
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DR EMBL; FOEP01000001; SEP60382.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8Z7M3; -.
DR STRING; 657014.SAMN04488092_101331; -.
DR OrthoDB; 9800621at2; -.
DR Proteomes; UP000198634; Unassembled WGS sequence.
DR GO; GO:0008379; F:thioredoxin peroxidase activity; IEA:InterPro.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:InterPro.
DR CDD; cd03013; PRX5_like; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR037944; PRX5-like.
DR InterPro; IPR013740; Redoxin.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR10430; PEROXIREDOXIN; 1.
DR PANTHER; PTHR10430:SF16; PEROXIREDOXIN-5, MITOCHONDRIAL; 1.
DR Pfam; PF08534; Redoxin; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Antioxidant {ECO:0000256|RuleBase:RU366011};
KW Oxidoreductase {ECO:0000256|RuleBase:RU366011};
KW Peroxidase {ECO:0000256|RuleBase:RU366011};
KW Redox-active center {ECO:0000256|RuleBase:RU366011};
KW Reference proteome {ECO:0000313|Proteomes:UP000198634}.
FT DOMAIN 1..178
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT ACT_SITE 56
FT /note="Cysteine sulfenic acid (-SOH) intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR637944-1"
SQ SEQUENCE 183 AA; 20170 MW; 6E88BB53AFBFA062 CRC64;
MQAGLKLPDV TFRTRVRDEA VGGTNPFRWQ DMTTADYFAG KRVILFSLPG AFTPTCSTYQ
LPGFEKNAET FAALGIDGIY CMSVNDSFVM NKWAEMQGIK TVKVIPDGSG EFTRKVGMLV
AKDNLGFGMR SWRYAAVINN GVVEAWFEEP GRCDNHGEDP YGESSPENLL KYLEAKASGI
AAE
//
