ID A0A1H8ZDX1_9ACTN Unreviewed; 2667 AA.
AC A0A1H8ZDX1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Non-ribosomal peptide synthase domain TIGR01720/amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SEP61908.1};
GN ORFNames=SAMN04487983_1001120 {ECO:0000313|EMBL:SEP61908.1};
OS Streptomyces sp. yr375.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761906 {ECO:0000313|EMBL:SEP61908.1, ECO:0000313|Proteomes:UP000198568};
RN [1] {ECO:0000313|EMBL:SEP61908.1, ECO:0000313|Proteomes:UP000198568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR375 {ECO:0000313|EMBL:SEP61908.1,
RC ECO:0000313|Proteomes:UP000198568};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FOFF01000001; SEP61908.1; -; Genomic_DNA.
DR STRING; 1761906.SAMN04487983_1001120; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000198568; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000198568}.
FT DOMAIN 965..1038
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2555..2630
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 945..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1249..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2641..2667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2652..2667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2667 AA; 280824 MW; 0739FFBF0E99146F CRC64;
MPTDDRGSLP LTSAQAGVWF AQQLDPLRRD FAIGEYLEIH GAVDPGLFQE ALRRMLAETE
ALGMCFAEAD GVVRQRPAGR PPFRLETVDV SGAPDPLAAA EARMRAELDR PMDPATGDVH
RQLLVRTGPE SFCWLQGYHH IVADGVGGTL VARRVAAHYT ALVTGAAVPP SDATPWREIV
AEEEAYLGSG AREADRAFWR DVLADAPEPV GFAGRPAGSG PGAPRSTVVR VGGEVPADDA
RLLREAARAY GTRWSALVMA AAAAYLHRVN GTEDVVLGLP VTGRATAAAR RTPGMFSRVL
PLRLAVTGTT TIGDLVRRTT SGIKDVLRHQ RYRIEEVHTG ARLWDATVNL MSFDYGLTFA
GARATAHNLS VGPVDHLTVN VYDRGGDSPL TVQVEGAAAE TDAEQAHAHR ERFTRFLVAL
AAAGPEAVVD SLDLLTPDDE RRLAAFADGG AADTPTDRCL HDLFEEQAAR TPDAVAVVCD
GEEVTYAALD AWAEDVARRL RPLTEPGRPV GVRVRRSPAM VAALLGVLKA GGCYVPLDPA
LPAARVAYVV DRAGIGAVVA GPDTAGSLSE GVAVVPVGEA RETDSPYGAG RVAVPALSAA
YLLYTSGSTG EPKGVVVPHA AAVDFVHAHL AVAGIGAGQG GGERFLGFAA LSFDVSVLDV
FGALLSGGTL VLATDEERTD LDRLRSLMAR QAVTVADLPS ALLPLLDPGA LPALRFLSTG
GEAPSADAVA RWAAGGREVW NGYGPTEATV EVTMHRCAAG ADGRVPPIGR PMVNHRAYVV
DSRLRLLPPG AAGELCVAGT GLAQGYAGQP ALTAGRFVPD PFSAVPGERM YRTGDLVRWS
TDGDLEYLGR IDQQVKVNGY RVELGEIETV LSRHPSVRHA AVDVRPAPGG GRRLVAFVAP
EPGETLAAAA ELAAHLGEFL PHYMVPHTFV ALDALPLTAN KKVDRRALPT PGPDQEAPPA
APAREPAAGP EGTLCALFAD VLGRAVAPDD NFFFLSGDSI AALTLVSRAR ARGFAFTLGD
VFTHKTPAGL AAAVGAPAAT PEPAATAEAC GESAATPVMR WLLDGPGPIG RFSQSMTLTL
PADADDARLV RALQTVLDRH AALRIRVTEG PDGRPALVVG EPGSVDAARV LRRAAEPLDA
QTAGAAAAAE LDPAHGVLVR AVRWAGLGDL PDRLLLCVHH LAVDGVSWRI LLDDLATAWD
TAAADGDTPL LPPPGTGTPF RTWAAHLQDL AASPEVLAEL PYWRRTLTPD AGADAASPGR
DGTPAPWDRT PDPARDTADT ARARTLTLPP NVDADAASPQ RDDTPAPWDR TPDPARDTVG
TARTRMLTLP PETAGPLLTS VPAALGTGPA EVLLTALALA AHHPGVAGSG GPDSLLLDLE
GHGRADRTGR HDLSRTVGWF TTQYPVRLDL RGLDLAAARE GDGDALAELA GRVHGCLAAV
PDHGTGYGLL SRLNPATAGE LAALPQPRVL FNYLGRFDGA DDAPWTPAPG AGGLRAHADP
ALPLDHCLQI DALAVQEAAG PSLTAVLTWP EGLLAEDEAD ALADAWLAAL RLLAVSSAQA
APVAGSVRTD LAPAGVSRAD VDGLSERHPG LTDVLPLSPL QEGLFFHAAY DATGTDAYTG
QLVLTLDGPL DPGALRRACG ALLERHDALR AAFTDRGLDR PVQVVAGSVE VPWACADLTA
YPKEERDAVW ERLLADDRDR RFDLERPPLV RFTLVRTGAA RHRLLMTNHH ILWDGWSSAV
LLRELLTGYA ELTGVAPRAV AASAVPYRDH LAWLARQDRA AATAAWRTAL AGLDEPTLLG
SSDPNRLGAL PERTTVELSP EATARLTERA RSAGITLNSV VQGLWAILLA RLTARTDVVF
GGTVSGRTAP VAGVEQMVGL LINTLPVRFR VRDEETLLAA LARFQDEQAP LMDHQHLGLA
DIQRAAGLGT LFDTAVVVEN YPLDLAEMRD LGGEVRLAAV DGTDATHYTV NLLVLPGERL
RLHLDHRPDV LDARGALSVA EGLQRLLTAV AEEPRTPVGE VDVLSAAQHR LIAEWNDTAV
PVPATTLVEL LERQAARTPD ALATVFADER LTYAELDARA EALAAGLRAR GARPEEIVAV
ALHRSTELVV ALLAVLKSGA AYLPVDPSLP AERIAFMLSD AAPVLLLTTS DVAAGLPADA
RTPQLLLDAG RGGAAPVGVS GADVPAGPLP SHPAYVIYTS GSTGRPKAVV VEHSAIVNRL
LWMQDRYGLG PDDRVLQKTP FGFDVSVWEF FWPLSTGAAL VVAEPGGHQD PAYLARVIRR
ESVTTAHFVP SMLAAFVAEP AAAGCRSLRR VVCSGEALPE ELKNRFLDVL DVPLHNLYGP
TEAAVDVTHW ECRRADEGPV PIGRPIWNTA LHVLDPAGRP VPVGFPGELF LAGAGLARGY
LRRPALTAER FPLDPFGPPG SRMYRTGDIA RRRADGAVEY LGRTDDQVKI HGFRIELGEI
ETALARQAGV QQAAVVVRED TPGERRLVGY VVPEPETASE AAPEAAALRS ELARSLPEYM
VPLVVVVDAL PVTPNGKLDR RALPAPAAAP TGHEPPDGEI EELVAAVWGA VLGVADVGRL
DDFFALGGHS LSATRVAARL RQSLALELPL HTLFEQRTVA ALAAAVETAL LADIAASTAD
DALPPPSLEP STAPTSVVAH ASQGETS
//