ID   A0A1H8ZHZ5_9ACTN        Unreviewed;       338 AA.
AC   A0A1H8ZHZ5;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=L-gulonate 5-dehydrogenase {ECO:0000313|EMBL:SEP63964.1};
GN   ORFNames=SAMN04487983_1001173 {ECO:0000313|EMBL:SEP63964.1};
OS   Streptomyces sp. yr375.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1761906 {ECO:0000313|EMBL:SEP63964.1, ECO:0000313|Proteomes:UP000198568};
RN   [1] {ECO:0000313|EMBL:SEP63964.1, ECO:0000313|Proteomes:UP000198568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YR375 {ECO:0000313|EMBL:SEP63964.1,
RC   ECO:0000313|Proteomes:UP000198568};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072}.
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DR   EMBL; FOFF01000001; SEP63964.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H8ZHZ5; -.
DR   STRING; 1761906.SAMN04487983_1001173; -.
DR   OrthoDB; 9797931at2; -.
DR   Proteomes; UP000198568; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43161:SF23; (R,R)-BUTANEDIOL DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR43161; SORBITOL DEHYDROGENASE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198568};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          34..138
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
SQ   SEQUENCE   338 AA;  34603 MW;  6A7C4E2719B91C24 CRC64;
     MSEPSVRPGG TVMELVAPHV FAPTLRPVPE PAAGEVVVAM RALGLCGTDL HMYGGRAVEY
     PHVVGHDGAA VVTARGAGVT GVAVGERVTI DPVAHCGQCA ACTRGATQLC PDGGYLGMLG
     PGLLAEYVCV PARLLVPLPD AVSDLAATVL EPVAVALHLL ARVAPLLPKE PVPCAVVGGG
     PLGILLGVVL RHHGYAPHLF EPQETRRDLA AAVGLVAHPP EPIDLGDGPR LVVETSAAPA
     GVALADELAT PGSVVAVVGR APHSIAPPSV LLKELSLIGV KGGPGQYPEA VRLVADGVVD
     PETVVTHRFG WHEAAEAFRI SVDRPDLVVR TALVGAWR
//