ID   A0A1H8ZJ55_9FIRM        Unreviewed;       208 AA.
AC   A0A1H8ZJ55;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Thiamine-phosphate pyrophosphorylase {ECO:0000313|EMBL:SEP64257.1};
GN   ORFNames=SAMN02910289_00219 {ECO:0000313|EMBL:SEP64257.1};
OS   Lachnospiraceae bacterium RM5.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1200721 {ECO:0000313|EMBL:SEP64257.1, ECO:0000313|Proteomes:UP000199252};
RN   [1] {ECO:0000313|EMBL:SEP64257.1, ECO:0000313|Proteomes:UP000199252}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RM5 {ECO:0000313|EMBL:SEP64257.1,
RC   ECO:0000313|Proteomes:UP000199252};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004948}.
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DR   EMBL; FOFK01000002; SEP64257.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H8ZJ55; -.
DR   STRING; 1200721.SAMN02910289_00219; -.
DR   Proteomes; UP000199252; Unassembled WGS sequence.
DR   GO; GO:0009228; P:thiamine biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd00564; TMP_TenI; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR036206; ThiamineP_synth_sf.
DR   InterPro; IPR022998; ThiamineP_synth_TenI.
DR   PANTHER; PTHR20857:SF15; THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME; 1.
DR   PANTHER; PTHR20857; THIAMINE-PHOSPHATE PYROPHOSPHORYLASE; 1.
DR   Pfam; PF02581; TMP-TENI; 1.
DR   SUPFAM; SSF51391; Thiamin phosphate synthase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199252};
KW   Thiamine biosynthesis {ECO:0000256|ARBA:ARBA00022977}.
FT   DOMAIN          14..190
FT                   /note="Thiamine phosphate synthase/TenI"
FT                   /evidence="ECO:0000259|Pfam:PF02581"
SQ   SEQUENCE   208 AA;  23562 MW;  8801BFA5E19081C3 CRC64;
     MIIYMCNNKN PYIICITNRL LCEENFLERI KKITDTDISY LILREKDLDE ESYFELAGSV
     IKICNDAGKK CILHNFYDVA ISLNHKNIHL PIPVLKEIDD KKLNFFDIKG ASAHSIKEAE
     LAIKKNCNYI TLSHIFKTDC KKGLKEKGIG LIKEVKEKMD ICIYGLGGIN EKNASDVIKA
     GADGICIMSG FMKCDDPKSY VEKIRSSI
//