ID A0A1H8ZJE9_9ACTN Unreviewed; 529 AA.
AC A0A1H8ZJE9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=ATP-dependent DNA helicase RecQ {ECO:0000313|EMBL:SEP64441.1};
GN ORFNames=SAMN05421756_101265 {ECO:0000313|EMBL:SEP64441.1};
OS Microlunatus flavus.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Microlunatus.
OX NCBI_TaxID=1036181 {ECO:0000313|EMBL:SEP64441.1, ECO:0000313|Proteomes:UP000198504};
RN [1] {ECO:0000313|Proteomes:UP000198504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.6856 {ECO:0000313|Proteomes:UP000198504};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR EMBL; FOFA01000001; SEP64441.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8ZJE9; -.
DR STRING; 1036181.SAMN05421756_101265; -.
DR Proteomes; UP000198504; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:SEP64441.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 26..195
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 219..374
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 529 AA; 57256 MW; 422A11CDB21AE921 CRC64;
MSDKISDAAR TVFGRDRLRA GQREAVQALL DGRDALLVQP TGAGKSLAYQ LAAVLIDGPT
LVVSPLLALQ QDQAEHLEAY GDRTRARRIS SAETPKQREE ALAAARDGEV EFLFLAPEQL
ANDAVHAAVS SMRPSLVVVD EAHCVSSWGH DFRPDYLRLG ELLEGLGART IAMTATASLP
VRTDIVDRLH LTDVSIIVGG AARENIDLSV ERCVTERDQE ERVVAAAAAQ EGSGIVYVST
RKAAEHYAAL VADAGRTTTC YHAGLAKKAR EQAQADFMTS AVDVVVATSA FGMGIDKPDV
RWVLHAHIPE SPDEYYQQVG RAGRDGDPSA GVLYFRTEDL SLRRFQTVPV PKPSEVSRVL
AALATRPDAT AAEQAEVADV SLRKLQRIAN LVIEAGAEGE TVGVDEVRAR AEGYQTLQRS
RVEMVRGYAE TRRCRRQFLL AYLGESDTPR CERCDNCRSG AAAAEEAQDA AAPDSPFQPE
ERVSHASFGE GMVISVEGEE VVVLFDDVGY KTLSLPTVVE HDLLEPLDA
//
