ID A0A1H8ZVA8_9ACTN Unreviewed; 647 AA.
AC A0A1H8ZVA8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Cell division protein FtsI (Penicillin-binding protein 3) {ECO:0000313|EMBL:SEP68406.1};
GN ORFNames=SAMN05216481_101736 {ECO:0000313|EMBL:SEP68406.1};
OS Streptomyces radiopugnans.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=403935 {ECO:0000313|EMBL:SEP68406.1, ECO:0000313|Proteomes:UP000199055};
RN [1] {ECO:0000313|EMBL:SEP68406.1, ECO:0000313|Proteomes:UP000199055}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.3519 {ECO:0000313|EMBL:SEP68406.1,
RC ECO:0000313|Proteomes:UP000199055};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; FOET01000001; SEP68406.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H8ZVA8; -.
DR STRING; 403935.SAMN05216481_101736; -.
DR Proteomes; UP000199055; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:SEP68406.1};
KW Cell division {ECO:0000313|EMBL:SEP68406.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199055};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 52..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 95..262
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 306..621
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 69002 MW; 926B0361CE1524CB CRC64;
MSERPQRPQR PRRTQPAPRS AASRSARAPR PAARAPRPGP GTVRLGNPRP RLRLFGVLLT
LVMLAFTVRL LQVQAVDAST YAAKADVNRY ITVPLAAERG TVTDRDGVAL ATTVDAYDIT
ADPYLFTPDQ TKVPDAPAQA AELLAPILGV DEETLTERLS RKETRYVLLA RQQSPQVWRQ
ITDLKRVLAG RQRAGGGHHV LAGVYSEEHA KRVYPGGDLA AAVLGFVNSE GKGSGGLEAK
FDKVLAGKDG KITYAQSGGR QVPTAGEHEQ PARPGSDVEL TLDRDIQWAA QSAIEERVEK
SDADSGYVIV QDVRTGEILA MANAPGYDPG DLSTASASAL RNGAVEDAYE PGSTSKVMSM
AAVLEEGVAT PGTHVVVPNR LPRADRSFAD DIDHPTWHLT LNGVLAKSSN IGTILAVEQL
GDTQTEANRV LHSYLRKFGL GQRSGLDFPG ETPGILADPG DWNASQQYTI PFGQGLSINA
VQAASVYSTI ANGGVRVEPS LVRGTTGPDG EWKPAPEPQR TRVVGEKTAT TLAAMLESVV
ADMEGTGTTA RIPGYRVAGK TGTANRVDPE TGRYNGYTSS FAGFAPADEP RVTVYCAVQN
PKKGSYFGSE VCGPVYQQVM KYALKALRIP PTGAEPPRLP VTFDPGD
//
