ID A0A1H9CTF3_9BACT Unreviewed; 761 AA.
AC A0A1H9CTF3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=SAMN05444359_10511 {ECO:0000313|EMBL:SEQ04500.1};
OS Neolewinella agarilytica.
OC Bacteria; Bacteroidota; Saprospiria; Saprospirales; Lewinellaceae;
OC Neolewinella.
OX NCBI_TaxID=478744 {ECO:0000313|EMBL:SEQ04500.1, ECO:0000313|Proteomes:UP000199021};
RN [1] {ECO:0000313|Proteomes:UP000199021}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24740 {ECO:0000313|Proteomes:UP000199021};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; FOFB01000005; SEQ04500.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9CTF3; -.
DR STRING; 478744.SAMN05444359_10511; -.
DR InParanoid; A0A1H9CTF3; -.
DR Proteomes; UP000199021; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR011815; PBP_1c.
DR InterPro; IPR009647; PBP_C.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02073; PBP_1c; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF15; PENICILLIN-BINDING PROTEIN 1C; 1.
DR Pfam; PF06832; BiPBP_C; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000199021}.
FT DOMAIN 33..195
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 273..404
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT DOMAIN 671..757
FT /note="Penicillin-binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06832"
SQ SEQUENCE 761 AA; 83922 MW; 78D9D31D8660E4CB CRC64;
MPRPLFDAPL STQLLSAEGE LLSARIAADG QWRMPAADSV SSRLKAAVLV YEDRRFRQHW
GVSLSGIGRA IRDNWQAGAV VSGGSTITMQ VARMARGNKS RTLGQKVMEA LWATRMEWRY
DKDEILAFWL ANAPFGGNVV GAEAAARRYY GRSPEELSWA EAATLAVLPN SPALIHPGRA
RDALRDKRDR LLDQLAAAGH CSSEEVGLAR LEPLPERPHP LPREAGHLLE RLRSDKGAGR
YRSSLNAALQ RRVAGMVREH HLALAGNGIH NAAAMVTEVS SGRVVAYVGN VPDLAPAFAP
DVDVITSPRS PGSLLKPMLY ALAQEEGRIS SKQLLPDVPT SFGDFRPANF YRDYDGAVPA
DEALARSLNI PFVYLLQDYG TERFHAALRE YGFKQLLRGP DHYGLSLVLG GGEITMEEIN
AWFLGMARQQ RYFYERQGWY AEADFQPATL LDAESRDPLA DLNQVAGAVG AGAGFKTLEA
LTALNRPDET GASHRFSSHQ KVAWKTGTSF GFRDAWAVGC TPAYVVSVWT GNADGEGRAG
LVGVRAAAPL LFRILRALEQ DGGEAPRWFE APYDDMTEAT VCQTSGYLAG PDCPTTAEWQ
AANAERASVC RFHQRIFTTP EGDYRVNQDC APGQLVTGRQ FQLPSRQAYF YRRRHPEYRS
LIPWHPDCAN AADAGSPMQF IYPHGNGAIS AGKNWHGEIE PVFFELSHQK EESTVHWHID
GEFMGSTTRF HSLAVEITEG RHTITVVDED GARLERRFVV R
//
