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Database: UniProt
Entry: A0A1H9DB54_9ACTN
LinkDB: A0A1H9DB54_9ACTN
Original site: A0A1H9DB54_9ACTN 
ID   A0A1H9DB54_9ACTN        Unreviewed;       509 AA.
AC   A0A1H9DB54;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=DNA-3-methyladenine glycosylase II {ECO:0000256|ARBA:ARBA00012000};
DE            EC=3.2.2.21 {ECO:0000256|ARBA:ARBA00012000};
GN   ORFNames=SAMN04487983_100383 {ECO:0000313|EMBL:SEQ10772.1};
OS   Streptomyces sp. yr375.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1761906 {ECO:0000313|EMBL:SEQ10772.1, ECO:0000313|Proteomes:UP000198568};
RN   [1] {ECO:0000313|EMBL:SEQ10772.1, ECO:0000313|Proteomes:UP000198568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YR375 {ECO:0000313|EMBL:SEQ10772.1,
RC   ECO:0000313|Proteomes:UP000198568};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-
CC         methylguanine, 7-methylguanine and 7-methyladenine.; EC=3.2.2.21;
CC         Evidence={ECO:0000256|ARBA:ARBA00000086};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; FOFF01000003; SEQ10772.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H9DB54; -.
DR   STRING; 1761906.SAMN04487983_100383; -.
DR   Proteomes; UP000198568; Unassembled WGS sequence.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd00056; ENDO3c; 1.
DR   Gene3D; 3.40.10.10; DNA Methylphosphotriester Repair Domain; 1.
DR   Gene3D; 3.30.310.20; DNA-3-methyladenine glycosylase AlkA, N-terminal domain; 1.
DR   Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR035451; Ada-like_dom_sf.
DR   InterPro; IPR004026; Ada_DNA_repair_Zn-bd.
DR   InterPro; IPR010316; AlkA_N.
DR   InterPro; IPR037046; AlkA_N_sf.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR003265; HhH-GPD_domain.
DR   InterPro; IPR023170; HhH_base_excis_C.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR018062; HTH_AraC-typ_CS.
DR   PANTHER; PTHR43003; DNA-3-METHYLADENINE GLYCOSYLASE; 1.
DR   PANTHER; PTHR43003:SF13; DNA-3-METHYLADENINE GLYCOSYLASE 2; 1.
DR   Pfam; PF02805; Ada_Zn_binding; 1.
DR   Pfam; PF06029; AlkA_N; 1.
DR   Pfam; PF00730; HhH-GPD; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM01009; AlkA_N; 1.
DR   SMART; SM00478; ENDO3c; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF57884; Ada DNA repair protein, N-terminal domain (N-Ada 10); 1.
DR   SUPFAM; SSF48150; DNA-glycosylase; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF55945; TATA-box binding protein-like; 1.
DR   PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198568};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          107..205
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000259|PROSITE:PS01124"
SQ   SEQUENCE   509 AA;  54951 MW;  5A5354DBD7FB311B CRC64;
     MQNGNGNGNG NGNGNGNGNG MYTDRERCVR AVRSKDARFD GWFFTAVLTT GIYCRPSCPV
     VPPKPANMVF HPSAAACQQA GFRACKRCRP DTTPGSPEWN QRADLVARAM RLIADGVVDR
     DGVPGLAARL GYSTRQIERQ LLAELGAGPL ALARAQRAQT ARLLIETTRL PMADVTFAAG
     FASIRTFNDT VRDVFALSPS ELRARVPQQN APATPGILQL RLPFRAPLNP DNLFGHLAAT
     GVPGVEEWRD GAFRRTLRLP YGHGIVALTP NPDHIGCRLT LSDLRDLTVA SSRCRRMLDL
     DADPVAVDDQ LRTDPLLAPL VDKAPGRRVP RTVDEAEFAV RAVLGQQVST AAARTHAARL
     VTAYGDPIDD PEGGLTHLFP TPEALAAVDP EHLAMPRTRR TTFTTLVGQL ADGTLNLGVD
     SDWAEARARL LALPGFGPWT VDVIAMRALG DPDAFLPTDL GIRRAAQQSG LPSTPAALTA
     RAAAWRPWRA YAVQYLWATD SHPINFLPA
//
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