ID A0A1H9E1F9_9BACT Unreviewed; 280 AA.
AC A0A1H9E1F9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN ORFNames=SAMN05444359_106214 {ECO:0000313|EMBL:SEQ19579.1};
OS Neolewinella agarilytica.
OC Bacteria; Bacteroidota; Saprospiria; Saprospirales; Lewinellaceae;
OC Neolewinella.
OX NCBI_TaxID=478744 {ECO:0000313|EMBL:SEQ19579.1, ECO:0000313|Proteomes:UP000199021};
RN [1] {ECO:0000313|Proteomes:UP000199021}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24740 {ECO:0000313|Proteomes:UP000199021};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin;
CC Xref=Rhea:RHEA:15613, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58351, ChEBI:CHEBI:58827; EC=1.3.1.76;
CC Evidence={ECO:0000256|ARBA:ARBA00001156};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005010}.
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DR EMBL; FOFB01000006; SEQ19579.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9E1F9; -.
DR STRING; 478744.SAMN05444359_106214; -.
DR InParanoid; A0A1H9E1F9; -.
DR OrthoDB; 45564at2; -.
DR UniPathway; UPA00262; UER00222.
DR Proteomes; UP000199021; Unassembled WGS sequence.
DR GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR028161; Met8-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028281; Sirohaem_synthase_central.
DR InterPro; IPR006367; Sirohaem_synthase_N.
DR NCBIfam; TIGR01470; cysG_Nterm; 1.
DR PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR Pfam; PF13241; NAD_binding_7; 1.
DR Pfam; PF14824; Sirohm_synth_M; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF75615; Siroheme synthase middle domains-like; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000199021}.
FT DOMAIN 165..191
FT /note="Siroheme synthase central"
FT /evidence="ECO:0000259|Pfam:PF14824"
FT REGION 256..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 280 AA; 29970 MW; 99573691F97C0ABD CRC64;
MTNPLYPAFF RLDRLQLLVV GAGEVGEEKL SFILKSSPNA RVVIVAPWMG EELKALLDKC
NDAARTQVQS ELDEAGFGGA TLEAARFEAE PAAGEWRTVA GGTVIWYARE FRSADVTIAD
LVVAATNFKD INLAVHAAAK AARRLTNIAD TPSLCDFYLG SIVTRGPLKI AISTNGQSPT
FAKRFRQFLE AELPELETTN LLDDLKIFRD RLTGDFKAKV RQLNAVTSSL LSSTAGEAAG
CRCPEGECLV EAAANTAPAA AAPAEPAEVP ETPDSNENKA
//