ID A0A1H9E1R8_9FLAO Unreviewed; 1443 AA.
AC A0A1H9E1R8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Cobalt-zinc-cadmium resistance protein CzcA {ECO:0000313|EMBL:SEQ19700.1};
GN ORFNames=SAMN05444005_10945 {ECO:0000313|EMBL:SEQ19700.1};
OS Flavobacterium urocaniciphilum.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1299341 {ECO:0000313|EMBL:SEQ19700.1, ECO:0000313|Proteomes:UP000198648};
RN [1] {ECO:0000313|EMBL:SEQ19700.1, ECO:0000313|Proteomes:UP000198648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27078 {ECO:0000313|EMBL:SEQ19700.1,
RC ECO:0000313|Proteomes:UP000198648};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613}.
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DR EMBL; FOEI01000009; SEQ19700.1; -; Genomic_DNA.
DR STRING; 1299341.SAMN05444005_10945; -.
DR OrthoDB; 9758757at2; -.
DR Proteomes; UP000198648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR InterPro; IPR003423; OMP_efflux.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000198648};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 877..896
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 903..922
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 928..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 976..995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1033
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1045..1061
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1443 AA; 160496 MW; 98F11633F8BF81B0 CRC64;
MLNNIIEYSV KNKLIIALFT LILIGFGIYN VQKLPIDAVP DITNNQVQVI TVAPSFGATD
IERLVTFPIE QVNANISGLK EIRSFSRFGL SLVTIVFEDD VDVYWARQQV AERLQQVQSQ
LPQGMGIPEL GPISTGLGEI YQYVVRAKKG YEQKYDVSEL RTIQDWIVKR QLAGVKGVAE
VSSFGGKLRQ VEISIQPNKL NANGITITDV FDALEKNNQN TGGAYIEKEA SVLFIRSEGL
IQNLEAIENT PITTKSGVPL FIKDVAEVKN GFATRYGAMC YNNEGEVSGA IVMMLKGANS
SEVIENVKER IAQIQKTLPE GVVIEPFLDR TKMVNNAIGT VEKNLIEGAL IVIFVLVIFL
GNLRAGLLVA SVIPLSMLFA IIMMNLFGVS GNLMSLGALD FGLIVDGAVI IVEAVIHQIF
HRHQNEETIS LSQEEVNKEV NSSAKKMMNS AVFGQIIILI VYLPIFTLQG IEGKMFKPMA
QTVAFALIGA FILSLTYIPM MSAVVLKNIK HNPQSFSERM MAFLERIYLM RLIQALHNKK
KIIIGTIIAF VISLVVMSQL GGEFIPSLEE GDFAVETRVL TGSNLNTSIA STQKAAGILK
SRFPEVEKVV TKIGSGEVPT DPMPMEAADM MVILKDKKEW TSAETFNELS DKMSAALQEV
PGITVGFQYP VQMRFNELMT GARQDVVCKI YGEDLDTLSK YANKVGKIVN SIKGAKDLYV
EPIGGMPQVV IEYKRNVLAQ YQLNVTDVNR VVNASFAGQS AGLLFEGERR FDVVVRVNSN
EKQNLQDIQN LLIPTPSGSQ VPLQVIADVK IINGPNQIQR EDTKRRIVVG FNVHESDVQS
LVEEMKQKVE AKIKFPTGYY ITYGGSFENL NAAKDRLMIA VPISLLLIFL LLYFAFKSVK
HALLIYTAIP LSTIGGILFL AFRGMPFSIS AGVGFIALFG VAVLNGIVLI AEFNAQKKLG
KTDITEIILI GTKKRLRPIL MTAFVASLGF LPMAISNGSG AEVQRPLATV VIGGLLIATF
LTLFILPILY MLFEKKSSLS IPKNGIAVLF LFMSISGIAQ NKSTLNQVFE KGLANNLVVK
NEKQRVIAAQ VLVKSANEIP SLNLVGEYGQ LNSAFNDNRI GITQNISFPF LNAKKKNWYQ
IQTEIAQLNY KTSENEVKRA ITQNFYDLIY ALEREKVLKQ SDSIYNQFLN KAKMRLKLGE
TNHLEKEGAQ LAVAKISADL KKNQELIYQL QLQMQYLIQS DEVVFPSYKD VKIEYLTSSD
FVSNNVQLQV IEKEKMANEA AIKIEKAALI PEISLGYFSM TMQGMGANDV LYNSGTRFQS
FQMNLGIPIF NGANKARREA FKINSSILNN QSDLQKKQLE NIWQSFENKR QNDLIVLKNY
EESVLPGAKL MITTANNQIY KGEINYMEWS WIMNQALESR LDYLEKVKSY NDAIIQMLYQ
TTN
//
