ID A0A1H9E7S9_9FIRM Unreviewed; 813 AA.
AC A0A1H9E7S9;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains {ECO:0000313|EMBL:SEQ21695.1};
GN ORFNames=SAMN02910289_01527 {ECO:0000313|EMBL:SEQ21695.1};
OS Lachnospiraceae bacterium RM5.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1200721 {ECO:0000313|EMBL:SEQ21695.1, ECO:0000313|Proteomes:UP000199252};
RN [1] {ECO:0000313|EMBL:SEQ21695.1, ECO:0000313|Proteomes:UP000199252}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RM5 {ECO:0000313|EMBL:SEQ21695.1,
RC ECO:0000313|Proteomes:UP000199252};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FOFK01000007; SEQ21695.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9E7S9; -.
DR STRING; 1200721.SAMN02910289_01527; -.
DR OrthoDB; 9790669at2; -.
DR Proteomes; UP000199252; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR037522; HD_GYP_dom.
DR PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR PANTHER; PTHR45228:SF5; CYCLIC DI-GMP PHOSPHODIESTERASE VC_1348-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13487; HD_5; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51832; HD_GYP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199252};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 48..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 596..812
FT /note="HD-GYP"
FT /evidence="ECO:0000259|PROSITE:PS51832"
SQ SEQUENCE 813 AA; 92154 MW; AA6F03D256E40212 CRC64;
MAGSKKDNQG LETFLSPLAV MAFAVGTSVG WGAFVVTSNT YLKQAGPLGS IIGLLIGAVI
MLFVCSNYHY ISNKNIYKED VFTYTKNIFG YDRAFLIAWF VFLLYISIFW ANATAIPLFA
RYLIGDFFCF GHLYTLFGYK VFLGEILLTI AVIWITAFIL INSKKLVSKV MIILMALFLL
GVVCCFIAIL VKKPDDISLF SPSFSKGSNS FKQIISVAFI SPWAFIGFES VMHSSQEFSF
SKNKIFKILA GSVVITTLLY VFLILISVGA YPGECSSWWE YINNLFKYDG LDGLPIFFTA
KTYLGNIGIV LMFITLFSLV VTSLISNTWA LIRLMYVAAK QSVISEKYTV LNKKKVPARA
VIAVAVVSSF VPFLGRSAIG WIVDVTTIIA TLLYGVVSVA TMKCAKKNND KKHFVFGLIV
LLCMIVFGIS QLAPIFDAGS LEAETYLIFI LWSLFGMIFF HRVISKDHAR HFGRAIIVWV
VFISFIIILG FVWMNKIKNR ETKKVIFNLH EFHEKEINDE INSKGNVDKN NRVHDISEDE
YIDTQIDRLD KVELVTISVV LGLFSIAVFG LISNYSSMRK YETLLENEVA KKTAHILEMH
NNLVLGMATM VESRDNSTGG HIKRTSDLVR ILVEEIKKDE DREESIDTYI KNNENFYENV
IKAAPMHDLG KIAVDDVILR KPGRFTNEEF AIMKTHAKEG ERILTEILKN TDDEKFRDVA
KNMAHFHHER VDGSGYPEKL KDEEIPLEAR IMAIADVYDA LVSKRVYKEK MSFEQADKII
LEGMGTQFDK RLEKYYLSAC PKFEEYYSSL QDE
//
