ID A0A1H9ES74_9BACI Unreviewed; 800 AA.
AC A0A1H9ES74;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:SEQ28452.1};
GN ORFNames=SAMN05216362_11029 {ECO:0000313|EMBL:SEQ28452.1};
OS Piscibacillus halophilus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Piscibacillus.
OX NCBI_TaxID=571933 {ECO:0000313|EMBL:SEQ28452.1, ECO:0000313|Proteomes:UP000199427};
RN [1] {ECO:0000313|EMBL:SEQ28452.1, ECO:0000313|Proteomes:UP000199427}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21633 {ECO:0000313|EMBL:SEQ28452.1,
RC ECO:0000313|Proteomes:UP000199427};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; FOES01000010; SEQ28452.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9ES74; -.
DR STRING; 571933.SAMN05216362_11029; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000199427; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000199427}.
FT DOMAIN 8..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..305
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 800 AA; 88574 MW; F820FEA7D6A2163A CRC64;
MNRKIKRAAV LGSGVMGSGI AAHLANIGIP TLMLDIVPRE LTEAEEKKGL TLDDAVVRNR
IAASNKEKLK KQKPSPISSQ KSLELIEVGN FEDHMEQLKD VDWIIEVVVE NLDIKKKVYE
QVESHRKEGT IVSSNTSGIS INAMAEGRSE DFKKHFLGTH FFNPPRYLKL LEVIPNQDTD
PEVLEFMKTF GEDVLGKGVV EAKDTPNFIA NRIGTYGLLV TVKEMLNGGY TIGEVDSVTG
PMIGRPKSAT FRTLDVVGLD TFIHVAKNVY DNVEGEEKEA FVVPEFMRQM NEKGWLGAKS
GQGFFLKKKG KDGSQILELN PETLEYEERK KLKTQATEMA KQEKGPKRKV RAIVNANGDR
AGELVWNISK PTLIYSAQLV GEIADDINAI DEAMKWGFGW ELGPFEMWDA IGVKQSVERM
KEEGASVPNW ITEMLEEGYE TFYKTENGKV YFYHNGEYVE KTFNPKEINL KLHKEANGVI
KKNAGASLID LGDDVALLEF HSQSNAIGLD TIQMINQALE EVNKNYKGLV IGNQGKNFCV
GANLGMMLME AQDYNFMELE LVVKQFQQAM MNIKYNEKPV VSAPFGMTLG GGTEVCLPAH
SVQASHETYM GLVEVGVGLI PGGGGNKEYY IKQLSGLPEG VDLDLQKITN DVFEKIAMAK
VSTSAAEAFE NGLLDDRTDH ISVNGDHLIH DAKQKVISLS DAGFKPLKRQ KVPVVGETGF
ATMLLGAKGL ANSGYASEHD LKIAEKLAFV LAGGRLKYGT LVDEDYLLDL EREAFLSLIG
EPKTQQRMQH MLLKGKPLRN
//