ID   A0A1H9EXX9_9LACT        Unreviewed;       455 AA.
AC   A0A1H9EXX9;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=PTS system, sucrose-specific IIC component {ECO:0000313|EMBL:SEQ30616.1};
GN   ORFNames=SAMN04488558_10810 {ECO:0000313|EMBL:SEQ30616.1};
OS   Ignavigranum ruoffiae.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Aerococcaceae; Ignavigranum.
OX   NCBI_TaxID=89093 {ECO:0000313|EMBL:SEQ30616.1, ECO:0000313|Proteomes:UP000198833};
RN   [1] {ECO:0000313|EMBL:SEQ30616.1, ECO:0000313|Proteomes:UP000198833}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15695 {ECO:0000313|EMBL:SEQ30616.1,
RC   ECO:0000313|Proteomes:UP000198833};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FOEN01000008; SEQ30616.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H9EXX9; -.
DR   STRING; 89093.SAMN04488558_10810; -.
DR   OrthoDB; 9769191at2; -.
DR   Proteomes; UP000198833; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00212; PTS_IIB_glc; 1.
DR   Gene3D; 3.30.1360.60; Glucose permease domain IIB; 1.
DR   InterPro; IPR036878; Glu_permease_IIB.
DR   InterPro; IPR018113; PTrfase_EIIB_Cys.
DR   InterPro; IPR003352; PTS_EIIC.
DR   InterPro; IPR013013; PTS_EIIC_1.
DR   InterPro; IPR001996; PTS_IIB_1.
DR   PANTHER; PTHR30175:SF7; NEGATIVE REGULATOR OF SACY ACTIVITY; 1.
DR   PANTHER; PTHR30175; PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN; 1.
DR   Pfam; PF00367; PTS_EIIB; 1.
DR   Pfam; PF02378; PTS_EIIC; 1.
DR   SUPFAM; SSF55604; Glucose permease domain IIB; 1.
DR   PROSITE; PS51098; PTS_EIIB_TYPE_1; 1.
DR   PROSITE; PS01035; PTS_EIIB_TYPE_1_CYS; 1.
DR   PROSITE; PS51103; PTS_EIIC_TYPE_1; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198833};
KW   Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        176..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        206..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        250..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        423..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          4..87
FT                   /note="PTS EIIB type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51098"
FT   DOMAIN          107..455
FT                   /note="PTS EIIC type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51103"
FT   ACT_SITE        26
FT                   /note="Phosphocysteine intermediate; for EIIB activity"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00421"
SQ   SEQUENCE   455 AA;  49204 MW;  A9C74B4416BDD453 CRC64;
     MKHRQTVEQL LAAIGGQENL KLAEHCATRL RLILHDNNKL NKDEAEQIQG IKGYFYSTGQ
     HQFVFGTGTV NEVYQDLLSV IDQNKLAEGD IKSEVYQNMT PVQKVVRTFA DILVPLIPAL
     VTTGLLMGLR GFLVELGLEM TPEFATMFGV LTDTAFAFLP VLIAYSASKK FGGNPIMGIV
     IGLMMVAPQL PNAYSVGSGD AEALNIFGIN IVAYQGSIFP AIIAGWLIAK IEQWCRTWVP
     KMMDLVVTPF LSLLITFVTI IFLLGPVIQA VEHFVINGIV TLIEAPLGLG YIVFGGLQQA
     IVVTGLHHSI GVIELSLLSE TGRNVIQPLT TASMAGQFGA AIGAAFLVKD AVRRMNMINA
     SVPTLFGITE PLLFGVNLRS LRIFVSGIIG GAAGGLVTYL MHLTAPGMGI TFIPGLLFYT
     ESFGLLLNYL IVIGVSFAVA FVLVQAQRKY IVDEI
//