ID A0A1H9F9E3_9ACTN Unreviewed; 364 AA.
AC A0A1H9F9E3;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=SAMN05421756_103198 {ECO:0000313|EMBL:SEQ34580.1};
OS Microlunatus flavus.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Microlunatus.
OX NCBI_TaxID=1036181 {ECO:0000313|EMBL:SEQ34580.1, ECO:0000313|Proteomes:UP000198504};
RN [1] {ECO:0000313|Proteomes:UP000198504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.6856 {ECO:0000313|Proteomes:UP000198504};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; FOFA01000003; SEQ34580.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9F9E3; -.
DR STRING; 1036181.SAMN05421756_103198; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000198504; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd11642; SUMT; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SEQ34580.1};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SEQ34580.1}.
FT DOMAIN 113..321
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 364 AA; 37704 MW; 4FC6984E17C75F29 CRC64;
MQLDLDVTGR AVLVLGTARG TRLAVARLVR GGARVTLVAT DAGAPPGPDP SAPFRVVRAP
DADDSSRLLR LLGPAWLVVS VDPPRALRER VEQLAARLRV LTTTQEPAAA LGRVTLVGGG
PGPTGLLTLE GAQALAAADV VFHDRLAPTD DLPDLAPSAE LVDVGKTPYH HPVDQRSIEE
LLVDRARRGQ SVVRLKGGDP FVFGRGGEEV LACLAAGVPV RVVPGVSSAV AVPASAGIPV
THRGLSHAFT VISGHQRPTE DELDALARLG GTVVVLMGVV NLEQIARGLV RAGLDPATPA
AVVERGWSDS QRSTFSSLAT LADDARRLQV ASPAVVVIGD VVRLAADRAD ASLVLDGLPA
WTAP
//
