ID   A0A1H9HDR8_9BACT        Unreviewed;      1020 AA.
AC   A0A1H9HDR8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=type I site-specific deoxyribonuclease {ECO:0000256|ARBA:ARBA00012654};
DE            EC=3.1.21.3 {ECO:0000256|ARBA:ARBA00012654};
GN   ORFNames=SAMN05444359_112119 {ECO:0000313|EMBL:SEQ60460.1};
OS   Neolewinella agarilytica.
OC   Bacteria; Bacteroidota; Saprospiria; Saprospirales; Lewinellaceae;
OC   Neolewinella.
OX   NCBI_TaxID=478744 {ECO:0000313|EMBL:SEQ60460.1, ECO:0000313|Proteomes:UP000199021};
RN   [1] {ECO:0000313|Proteomes:UP000199021}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 24740 {ECO:0000313|Proteomes:UP000199021};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of DNA to give random double-stranded
CC         fragments with terminal 5'-phosphates, ATP is simultaneously
CC         hydrolyzed.; EC=3.1.21.3; Evidence={ECO:0000256|ARBA:ARBA00000851};
CC   -!- SIMILARITY: Belongs to the HsdR family.
CC       {ECO:0000256|ARBA:ARBA00008598}.
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DR   EMBL; FOFB01000012; SEQ60460.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H9HDR8; -.
DR   STRING; 478744.SAMN05444359_112119; -.
DR   InParanoid; A0A1H9HDR8; -.
DR   OrthoDB; 9758243at2; -.
DR   Proteomes; UP000199021; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009035; F:type I site-specific deoxyribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1570.50; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR007409; Restrct_endonuc_type1_HsdR_N.
DR   InterPro; IPR040980; SWI2_SNF2.
DR   PANTHER; PTHR42927; HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR42927:SF1; HELICASE SUPERFAMILY 1 AND 2 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF04313; HSDR_N; 1.
DR   Pfam; PF18766; SWI2_SNF2; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199021};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747}.
FT   DOMAIN          275..539
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|SMART:SM00487"
SQ   SEQUENCE   1020 AA;  115454 MW;  6F4DFD9EE967411E CRC64;
     MTNQHTKEAA YESVIENHLL QNGYVSLPSN TFDRERAIFG TPLLDFIRTS QPKAWARLEK
     LLGEQTGEQI LRDLCKWLEI HGVLATLRHG FKCYGRKLFA AQFAPVHGMN PDADAAYAAN
     ICGLTRQLYY SPSNTKSLDL VLSLNGIPLM TVELKNQGSG QTVDDAVNQY RKDRDPRELI
     FKFKARTLVH FAADTDSVQM TTRLAGSTTY FLPFNRGNGG SAGNPPVKKG GGYRTAYLWE
     EVLQRDSFLD LVGRFIHLQT DEKRTDEGRK ITKETMIFPR YHQLGAVRQL VTKARADGPG
     SNYLVEHSAG SGKSNTIGWL AHRLASLHTS TDARVFDSVV VITDRRVLDK QLQQTIYQFE
     HKLGVVEKID KHSRQLAEAL VNGTPIIITT LQKFPFVTKQ LEELAEEGGA AASAMQGMKS
     REDGVLPTRR FAVIIDEAHS SQGGETAADL KQVLGGEDLV DEAKRRAAED EVTDMDELYR
     NMAKRGRQAN VSFFAFTATP KHKTYKIFGE AGKASHRYTM RQAIEEGFIL DVLKNYTTYA
     TYFKLVQKSG EELSVDKSQA ARALAKMLRT HPYNIAQKTQ VMVEHFNAVT KHKIGGRAKA
     MVVTGSRLEA VRYKEKFDEY IRTKGYEVKS LVAFSGVVND DKVPAVTYTE VEMNNGIKER
     ELPEKFASPE YHVLLVAEKY QTGFDQPLLH TMYVDKRLAG IQAVQTLSRL NRNHPLKEDT
     FVLDFVNDRE EIKQAFSDYY EGATIGEEAD PAALYRLKLE LEADGIITET EVDDFAAIYF
     RPRSRQSPAD HRQMNEALDP AVTRFAALLA SDEPEAEQWR GKLASYRSLY GFLSQVLPYQ
     DSELEKLFVY LRYLSPKLPR RKGVEAYDFD DDVRLEYYRL QKISEGSISL AKDYARPLDG
     PTELGVGMVR EPEVALRTLI DRLNDRFGTD FNPADQLFFD QMVATAVADE EIIEAAAANP
     KDKFKLIFEK LLRTLFSERI DQNEEIFARY MNDGVFHEIV TSWLADTAYD DLRQRNPPNE
//