ID   A0A1H9I2Q0_9GAMM        Unreviewed;       759 AA.
AC   A0A1H9I2Q0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Competence protein ComEC {ECO:0000313|EMBL:SEQ68890.1};
GN   ORFNames=SAMN03080615_02392 {ECO:0000313|EMBL:SEQ68890.1};
OS   Amphritea atlantica.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Oceanospirillaceae; Amphritea.
OX   NCBI_TaxID=355243 {ECO:0000313|EMBL:SEQ68890.1, ECO:0000313|Proteomes:UP000198749};
RN   [1] {ECO:0000313|Proteomes:UP000198749}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18887 {ECO:0000313|Proteomes:UP000198749};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FOGB01000006; SEQ68890.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H9I2Q0; -.
DR   STRING; 355243.SAMN03080615_02392; -.
DR   OrthoDB; 9761531at2; -.
DR   Proteomes; UP000198749; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR004797; Competence_ComEC/Rec2.
DR   InterPro; IPR025405; DUF4131.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF13567; DUF4131; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        48..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        277..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        320..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        404..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        456..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          518..703
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   759 AA;  83530 MW;  58DB9AB9B650117E CRC64;
     MIGIALGVLL VAWLPRLISF PTLTLLLTLL LLCLLLSCRG FLSSGVRIQI AGLLFGVIYA
     TGWGYLNLSQ RMPMDMPAQE FSVSGTVTGL PQNRPAMIRF SFDVDHYSPS LPGADLKHLQ
     LSWYHPEGEI VPGQQWLFKV RLKPPRGLMN PGSSDYETRL FAEQINARGY LLSARLIRGP
     GESGAQQIAY LRYRIAEWLS QLSLTDRSEA TIRALLLGDK QGLKDDQWRV LRQTGTVHLV
     VISGLHIAIA CLIGYWLGSL VQWLAGRVLP GQADIRAYRI VPALLLASSY ALLAGFSIPT
     QRALIMALSM LLPGLFNRHL GIWTRFQLAL VIVLLLQPLS FYQPGFWLSF AAVGALLLST
     TTNPVSYRLK AVVATQWSVF LGLFPLLLFW LGQVALIAPL INIVAIPLLT FILIPGVVLG
     VLLCLVNAEL GSALLNGLLN QFWLLLQVCA PSDGQAMLFS RPALLPVLLG GLAAILLNLP
     RWMGVGFFAL LMLTVLIFPP EQPVDQGDFR ATVADVGQGL AVLIETSSKA VLFDTGAAYR
     GRSTARFTLI PMLESRNISQ LDRLIISHKD NDHAGGYADL AETFTVKALD SGSPAIRRRL
     PAQPCVPGDS WEWDGVRFSY IQPAGLKQTN ENNRSCVLLV QSENCSILIP GDIESSVEQQ
     IMNTHPGLHV NWLVAAHHGS RFSSSAEWLN GLRPDWVLFS SGFDNPYGHP AREIIDRLQL
     LKLNWLNTSD SGAVIIQGSA DHCLTESYRD QKKRYWSAG
//