ID A0A1H9IT73_9PSEU Unreviewed; 6670 AA.
AC A0A1H9IT73;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Acyl transferase domain-containing protein {ECO:0000313|EMBL:SEQ77717.1};
GN ORFNames=SAMN05216188_10564 {ECO:0000313|EMBL:SEQ77717.1};
OS Lentzea xinjiangensis.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Lentzea.
OX NCBI_TaxID=402600 {ECO:0000313|EMBL:SEQ77717.1, ECO:0000313|Proteomes:UP000199352};
RN [1] {ECO:0000313|Proteomes:UP000199352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.3525 {ECO:0000313|Proteomes:UP000199352};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
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DR EMBL; FOFR01000005; SEQ77717.1; -; Genomic_DNA.
DR STRING; 402600.SAMN05216188_10564; -.
DR Proteomes; UP000199352; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 3.
DR CDD; cd00833; PKS; 4.
DR Gene3D; 1.10.287.1960; -; 1.
DR Gene3D; 3.30.70.3290; -; 4.
DR Gene3D; 3.40.47.10; -; 4.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 4.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 6.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 4.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 4.
DR Pfam; PF02801; Ketoacyl-synt_C; 4.
DR Pfam; PF08659; KR; 4.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF21089; PKS_DH_N; 3.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 4.
DR SMART; SM00826; PKS_DH; 3.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 4.
DR SMART; SM00825; PKS_KS; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 4.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 9.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 4.
DR SUPFAM; SSF53901; Thiolase-like; 4.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 4.
DR PROSITE; PS52004; KS3_2; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SEQ77717.1}.
FT DOMAIN 34..458
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1546..1624
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1645..2062
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3018..3093
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3109..3524
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4957..5032
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5047..5467
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 6514..6589
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 461..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2070..2106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 5..32
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 6670 AA; 695070 MW; 422861207DA05745 CRC64;
MSTSSEKVVE ALRAAMKEAE RLRKQNRQLV AAATEPIAII GMACRYPGGV SSPEDLWELV
SSGRDAITGF PADRGWDVDA LLGGGADERG HSVSVQGGFL DGIADFDPAF FGISPREAVT
MDPQQRLLLE VSWEALERSG IDPASLRGSR TGVFIGTNGQ DYEHLLIRGL DDATGDVGTG
IAASAESGRI SYALGLEGPT LTVDTACSSS LVALHLAVHS LRAGECSLAL AGGVNVMCTP
GSLVEFSRQG GLARDGRCKA FSDDADGTGW SEGVGVLALA RLSDALALGY PVLAVVRGSA
VNSDGASNGF TAPNGRAQQR VIRAALDRAG LAPSDVDVVE AHGTGTPLGD PIEARSLLAA
YGQDRPAPLL LGSVKSNIGH TQAAAGVAGV IKMVQAMRHG VVPATLHVSR PSTHVDWSAG
SVQLATSAVS WPASGRAPRA AVSSFGVSGT NAHVILEGAT PTPVSVDNSA PVDNSADVDL
AEPESSASRG TLGVGTSDSP RGAQAESIPW LVSAKSEASL AAQVERVCAL DGDPVDIGFS
LATTRALFEH RAVLLDGVEI ASGLARRTEA ALLFSGQGAQ RVGMGKGLHE AFPVFREAFD
EALSHLPAGL RDIMWGDEEA LNRTGATQPA LFAFEVALYR LLESFGVTAA RVAGHSIGEI
AAAHVAGVFS LEDAAKLVTA RARLMEELPP GGVMIALQAT EDEVVPRLTA GVSIAAVNSP
DSLVVAGAEA EVRAVIKRFE GRKTTQLAVS HAFHSPLMDP VLAEFREAIG GITFRSPTIP
MTGDVANPEY WVRHVRDTVR FHDAVTALGD RTLLEVGPDG VLSALTGAIP AQRRDRDERT
AFITALARLH VAGVAVDWTP FYAGGERVDV PTYAFQRDRY WPSVSVSAGD ATGLGLAPAD
HPLLGAAMTV AGSGELILTG TLSRTSWLAD HVVFPTAGVL ELAFRAADLT GHDRVEELTQ
TTPLVLPDSG AVQVQFQVGR DGVFRFHSRR GDRDWVEHAH GVFGDGVPAP ARDTEWPPRG
ATVVDLDGFY DETPYGEAFQ GLRAAWRRGH EVFAEVALPV DAKGFGVHPA LLDAATHAAA
FLGLDGVPAR WRGVSLHASA AEVVRVTLSA VDGEIALNAV DVAGDPVVSA ERVRFEPLGE
QAAAPGTDSL FRLDWVPVTP GPVTPGPGDA TVVHIRGDQS PESAHALAAE ALRTLQEATG
KLIFVTRGAV TGDDVAAAAV WGLVRSAQNE DPGRFLLADL DDAPESEALL PGLGALIDAG
ETQVVVRAGE VRAGRLARAA TTTGDWDLDG TVLITGGTGG LGAVLARHLA RRGQRRLLLV
SRRGPDAPGA ADLRDELTAL GTDVEVKACD VTDRAAVADL LGGVRLTAVV HAAGVLDDGV
LGSLTPERLS KVMRPKVDAA WHLHELAGDA LLVLYSSVSG VMGAAGQGNY AAANAVLDAL
ATHRHGLGLP ALSLAWGAWD TGMTSTLDSA DLRRMPLLTV EQGLALFDAA VGSGEPVLVP
LAPGGVARGH VPAILRGLVR TGRRTAAREV VAGGLLAKLV AQPTGERVRT IAGVVRAEAA
KVIGYPNADT VAPDKEFRAL GFDSLTAIEL RNALAAATGL TLPATLIFDY PTPLVLAEHL
LAELTGEGAD LDVVAQGGPD APGADDPIVI VGMACRFPGG VSTPEDLWRL LADGTDAIGG
FPSDRGWEQD ALAAGGTAEG GFLYGATEFD PAFFGISPRE ALAMDPQQRQ LLEVAWEAVE
RAGINAATLR GSKTGVFVGT NGQDYTNLVL RARGDIEGHA STGLAAAVIS GRLSYTFGFE
GPALTIDTAC SSSLVALHLA AQSLRSGESA LALVGGVTVM STPMNFAGFN AQGGLAADAR
CRAFSDDADG TGWAEGVGVL VVERQSDALR HGHTVLAVVR GSAVNSDGAS NGLTAPNGPA
QQRVIRQALA NAGLSAADVD AVEAHGTGTR LGDPIEAQAL LATYGRDRAG APLYLGAIKS
NLGHTQAAAG VAGVIKMVLA FQHGLLPRTL HVTSPSTHVD WSAGSVELLT SATPWPAVDR
PARAGVSSFG LSGTNAHVIL EAASPSAVPV VNSSPVDNSA DTDLVDEDSS VSRGTLGVGT
SDSPRGAQAE SIPLVVSAKS AAALDAQVER IRAVEADALD IGYSLLHRRV LFEHRAVLVD
GEVLARGEAS GKTLALLFSG QGSQRLGMGR ELYEAFPVFA HALDEVLTHL PGVREVMWGD
DAEALNRTEH TQPALFAVEV ALYRLVESFG IVPRLVTGHS IGEIAAAHVA GAFSLEDAAK
LVKARAELMQ ALPVGGVMIA LQATEAEVAP HLTPGVSIAA INAADSLVIA GSADEVRAVA
SRFDGRRTKQ LAVSHAFHSP LMEPMLDDFR RAIEGITFTA PAIPVVTTGD VTDPEHWVRH
VRDTVRFADN AGKLREQGAN AFLEIGPDGV LAALVDGAVP LLRKDRGEGK AFLAALARLH
VGGVDVDWSS FYRGGRGIDL PTYPFQHERF WPEVATGAVA ADPADAAFWT AVEQQDVASL
AATLDLDGET LAAVLPALSA WRGKRKAQST VESWLHAESW QPVAGLTAKP GRWLVIGAAD
PVLVRALGDV TEVIPEQTGR EHLAQKLAEH AQVPFDGVVS LLALDGGELA PITATTAVIQ
ALGDAGVLAP LWVLTRGAVS TGRADAVSAP WQAGVWGLGR VAALEHPNRW GGLVDLPAEL
DERAAQRCAA VLASDEDQAA IRAAGVFGRR IRVAPATSQE WQPTGTVVIT GGTGALGRHV
ARDLVARGAE KVVLLSRRGP DAPGAAEIAA EPGVEVVKCD AADRAELAAA LTPDVTAVVH
AAGVLDDGVL DGLTPERFAD VFRAKVTSAF LLDELTRDRH LDAFVLFSSV AGAIGNPGQA
NYAAANAVLD AIAARRHAHG LPATSIAWGA WAGDGMAGQE RVTRTIKSVG ASTLDPRLAV
AAMRGVVAET APTALIADLH HPQLLGALLS LRPSPVLAEL PGAREVLDDL AAARRDSESA
AAELRRSLRE LPAAERVEPV LELVRTRAAG VLGHSGKEAV ASDKAFRDIG FDSLTAVELR
NQLTEITGLA LPAGLVFDYP SPRALAEHLL ASLLGEAAET EDAAVVRTTD DIAIVGMACH
FPNGVDSPED LWRLLVAGED AMSDFPADRG WDLASLRTST TRGGFLTGVA DFDPAFFGIS
PREALAMDPQ QRLLLETSWE AVERAGVDPS SLRGSRTGVF IGTNGQDYQH VVMASNEDLE
GHAGTGLAAS VISGRISYVL GLEGPAVTVD TACSSALVAL HLAAQSLRAG ECSLALAGGV
TVMATPTSFS GFSRQGGLAP DGLCKAFSDS ADGTGWSEGV GVLVVERLSD AVAAGHPVLA
VVRGSAFNSD GASNGLTAPN GPAQQRVIRQ ALASGGLSPS DVDAVEAHGT GTVLGDPIEA
QALLTVYGQD RAHPLRLGSV KSNLGHTQAA AGVAGVIKMV LAFQHGLLPR TLHVTQPSSH
VDWSAGAVSL LTENTAWPPV DRPWRAGVSS FGISGTNAHV ILEAASPCAI SVDNSAPVDN
SLVVDLADQD SSASRGTLGV GTSDSPRGAQ AESIPIVVSA KSAAALRRQV ERIGALEAAP
VDIAYSLVRS RALFEHRAVL VDGAEVAAGV AGEHVLAVLF SGQGSQRLGM GKELYARFPQ
FADAFDDVLA HLDPGLKSVV WGDDEEALNQ TGNAQPALFA FQTALYRLLQ AFGIKPAHLA
GHSIGEIAAA HVAGVLSLQD AAKLVRARAS LMQALPRNGA MVAVQASEEE VTRHLTGTVS
IAAVNGPTSV VIAGDENDVL AVAGRFEKTK RLKVSHAFHS PLMEPMLAGF REAIGDIAFR
QPRIPISTTG DVTDPEYWVG HVRDAVRFAD NVARIPATRF LEAGPDGVLS ALVDGAVPAL
RKDRTETAAL ATALGRLHVD GITVDWTPWL TGGRLISLPT YPFDHERFWP KAAVGGRAGD
PAAHGLTSGG HPLLSAAISV AGADEFVLSG RISLATHPWL ADHVVGGAVL FPGTGFLDFA
IRAGDLVGCD RVDGLTIVVP LVLPDRDAVA VQVRVGPPDD HGRRPVGIHS RQHSGEWVQH
AGGTLAAGPH QTQLDTGEWP PATATPLDLE GFYDTLAEGG LAYGPVFRGL RQAWRHGDEV
LVEVALPESA DDAATFGVHP ALLDAALHAI TFVDGAGQGL PFEWNGVSLH AIGPSRLRVR
LKPAGGDAVE VTAADVEGAP VLSVKSLVVR TPSAGPAGNP VHDSLFRVDW VPVPVGEATG
IDARVVEISG DATTVHETTR QVLEILQNAE ERVVFVTRGA AAIGDEPVTD LAAAAAWGLV
RSAQAENPGR FLLVDLDEHS ELTPGMLLTE ESQLVVRHGT VHAGRLARLQ TGPALVPPPA
TPWRLDTTAK GSLDNLVLAP WTPEPLRGKQ VRVAVRAAGL NFRDVLNALG MYPGEAGSFG
AEAAGVVTEV GPDVEHLQVG DAVFGMLFGG MGPVGVIEEP YLTRLPAGWT FEQGASVPLV
FLTAYYALVE LGAVRPGEKV LVHAGAGGVG MAAIQLAKHL GAEVFATASE GKWDVLRGLG
LDDDHIGNSR DTSFARRFPR VDVVLNALTG EFIDASLGLL GEGGRFLEMG KTDLRENVPG
VFYRPFDLGE AHPDHIQRML VALMDLFGRN VLEPLPIRSW DVRRARDAFR FMSRAQHIGK
IVLTVPAGWD PDGTVVITGG TGGLGAELAR HLVARGVRKL LLLSRRGPDA PGAEELRRLD
ADVTIAACDV ADRDALAEVL DGHDVTAVVH TAGVLDDGVI ASMTPERLEK VLRPKADAAW
NLHTLVPDVH FVLYSSVSGV LGTAGQGNYA AGNAFLDALA QHRRSLGLPA VSLAWGAWTS
EVGMTGQMDA AALERLEKSS MPPISLEHGL ALFDAAIGAD EPLVVPARIV TGAAAATAVV
PPLLRNLLRG GRRTAARTQG TLALEGLRDV RPAERVRTLV DLVRGEAAAV LGHAAADAID
AGREFRQLGF DSLTSVELRN RLGTATGLTL PATLVFDYPT PQALAEHLLA ELFGGRTDVE
DSVRVSDEAV AIVGIACRFP GGVSTPEELW ELVLGGRDAI TGFPSDRGWD ENLVGDGAGQ
SVTGQGGFID GIADFDPAFF GISPREAVSM DPHQRLVLET SWEALERTGI DPLTLRGSRT
GVYVGASGQD YAHLVLASEQ ALEGYSGTGT SPSVIAGRVS YALGLEGPSM TIDTACSSAL
VALHLAVQAL RNGECSLALA GGVQVMSAPG AFREFSLQDG LARDGRCKPF SDNADGTAWS
EGIGVLVVER LSDALANGHD VLAVVRGSAV NQDGASNGLT APNGPSQQRV IRQALASAGL
KFADVDAVEA HGTGTTLGDP IEAQALLATY GQDRSEPLLL GSIKSNIGHT QAAAGVAGVI
KMVMALRHGL LPRTINFTAP SSHVDWTAGA VRLLQENTPW PATERPRRAG VSSFGISGTN
AHVILEAAPA VPELSDPGET IGVGTSRPPK GAPLVFSAKS PASLRAQIDR VAAVEADPFD
VGFTLLTRSR FEHRAVLLDG VEIARGQAGR PRLAVLFSGQ GSQRLGMGKE LYERFPAFRT
ALDEVLEHVG VREVMWGDDA EALDRTGNAQ RALFAVEVAL FRLAEAFGVE PDHVGGHSVG
EIAAAHVAGV LSLEDAAKLV NARATLMQAL PAGGAMIAVE AAEEEVTTTD SVSIAAVNGP
RSLVLAGEEH AVQRLADGFA EQGRKTKRLP VSHAFHSPLM EPMLDDFRAV VTALDFAAPR
IPLVSTVTGR LAGAEVTEPE YWVRHVRETV RFADAVTTLE AAGTGAFLEI GPDGVLSALV
GDAVPALRKD RDETTAWLTA LARLHVAGTD VDWAPAFEGT GAKRVTLPTY AFDHDRYWPT
PLARPADATG LGLGPADHPL LGAAMTVAGE DAVVFTNRLT AAFPETAFAE IAFRAADQVG
CGTVEHLVVT GPLTPGDLQV WVGAPDGGKR ALTVYSRHGD EPFTKIATGT LAEGEHHAGF
TVTEWPPKGA TAIGEQIWQS GDAVYAEVAL PEDVPDARFY GVHPALLDAA TRIVEDTGVP
VEWHGVSLHA VGAGTLRVRL RDGGFAAVDT TGAPVVSARE VVFGAPLTAQ RHQDSLFRLD
WVPAPETRPA ADVREVRFAG DTVEEAYEFA ARALELVQRS EDRLAFVTSG LAGATVEGLV
RTAQSENPGR FLLVDTDGSA PLPTGLLDAG ETWARVRDGQ VRVARLARVT GTAEPAAWDP
DGTVLITGGT GGLGAELARH LVAERGVRRL LLLSRRGGDA PEAVALQAEL AAHGATATFA
ACDVADLDAV RKAVEGVKLT AVVHTAGVLD DGTIGSLTPQ RLATVFRPKV DGAWNLHEAT
KEQDLDAFVL YSSVSGVLGS AGQGNYAAAN AFLDALAEHR RARGLVATSL AWGPWEQTGG
MTARLRDGAM DRIGRTGMPP LTVRQGMALF DDATSRDDAV LVPARIGTGR PTGPVAAVLR
GLVRGGKRTA GTGAESTPDL AATLAALPEE ERPKYLTDLV RGHAAGVLGH SSPAAIDTGK
QFRDLGFDSL TAVELRNSLA AATGLKLPAG LVFDHPTPAE LAAHLAGELL GGDDTAASVT
GELDRLEAAL AATPAEDLAR DGVAARLRAL LARYGGSQPD EDAVSDRINS ATVDDVFAFI
DNELGRRTER
//
