ID A0A1H9J3S5_9ACTN Unreviewed; 532 AA.
AC A0A1H9J3S5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Zn-dependent protease (Includes SpoIVFB) {ECO:0000313|EMBL:SEQ81438.1};
GN ORFNames=SAMN04487983_1008121 {ECO:0000313|EMBL:SEQ81438.1};
OS Streptomyces sp. yr375.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761906 {ECO:0000313|EMBL:SEQ81438.1, ECO:0000313|Proteomes:UP000198568};
RN [1] {ECO:0000313|EMBL:SEQ81438.1, ECO:0000313|Proteomes:UP000198568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR375 {ECO:0000313|EMBL:SEQ81438.1,
RC ECO:0000313|Proteomes:UP000198568};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M50B family.
CC {ECO:0000256|ARBA:ARBA00007931}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FOFF01000008; SEQ81438.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9J3S5; -.
DR STRING; 1761906.SAMN04487983_1008121; -.
DR OrthoDB; 9781963at2; -.
DR Proteomes; UP000198568; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06164; S2P-M50_SpoIVFB_CBS; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR008915; Peptidase_M50.
DR PANTHER; PTHR39188; MEMBRANE-ASSOCIATED ZINC METALLOPROTEASE M50B; 1.
DR PANTHER; PTHR39188:SF3; ZINC METALLOPROTEASE SLR1821-RELATED; 1.
DR Pfam; PF02163; Peptidase_M50; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:SEQ81438.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000313|EMBL:SEQ81438.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000198568};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 203..276
FT /note="Peptidase M50"
FT /evidence="ECO:0000259|Pfam:PF02163"
FT DOMAIN 290..342
FT /note="Peptidase M50"
FT /evidence="ECO:0000259|Pfam:PF02163"
FT REGION 1..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..151
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 532 AA; 55819 MW; 563B2B3CA0DF35C8 CRC64;
MVESGGTGRP RPDNEQSAEH PATPAPPATD LARTPDTPNP DAENPTDNTD NTGGTSNTGN
TGGTDNSGGT GSAGGNEKPA AGESQAEVQP EPEAQPKVEV KPEGAAQPKA EADPQPQPQP
EAEPQPEAGQ AVPPTPTLPK GPPPPRPPEQ PRGGILMGRP FGVPVYVAPS WFLVAALITW
VFGGQLDRVL PELGALRYLV SLFFAVAFYA SVLIHELAHT IAALRFKLPV RRIQLQFFGG
VSEIEKEAET PGREFWLAFV GPLLSLALSG LFYLAMQTVE PGTVPGVLLA GLMISNLIVA
IFNLLPGLPL DGGRMLRAVV WKITGKPMSG TVAAAWVGRA LAVSVLIGLP LLTQSGALGS
GAEDSVGMDT VTDALLAAIL AAIIWTGAGN SLRMARLREH LPELRARTLT RRAVPVETQT
PLSEALRRAN DAGARALVVV DAHGEPLSLV REAAIVGVPE HRRPWVAVSG LAQDLNDGMR
ISAELAGEDL LDVLRATPAT EYLVVEETGE IFGVLSAADV ERAFVKAMAR PS
//