ID A0A1H9J5S5_9RHOB Unreviewed; 337 AA.
AC A0A1H9J5S5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|ARBA:ARBA00019465};
DE EC=1.1.1.169 {ECO:0000256|ARBA:ARBA00013014};
DE AltName: Full=Ketopantoate reductase {ECO:0000256|ARBA:ARBA00032024};
GN ORFNames=SAMN04488092_11421 {ECO:0000313|EMBL:SEQ82117.1};
OS Thalassovita taeanensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Thalassovita.
OX NCBI_TaxID=657014 {ECO:0000313|EMBL:SEQ82117.1, ECO:0000313|Proteomes:UP000198634};
RN [1] {ECO:0000313|EMBL:SEQ82117.1, ECO:0000313|Proteomes:UP000198634}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22007 {ECO:0000313|EMBL:SEQ82117.1,
RC ECO:0000313|Proteomes:UP000198634};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH;
CC Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.169; Evidence={ECO:0000256|ARBA:ARBA00000784};
CC -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-
CC pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004994}.
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DR EMBL; FOEP01000014; SEQ82117.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9J5S5; -.
DR STRING; 657014.SAMN04488092_11421; -.
DR OrthoDB; 9796561at2; -.
DR UniPathway; UPA00028; UER00004.
DR Proteomes; UP000198634; Unassembled WGS sequence.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR21708:SF42; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Pantothenate biosynthesis {ECO:0000256|ARBA:ARBA00022655};
KW Reference proteome {ECO:0000313|Proteomes:UP000198634}.
FT DOMAIN 3..102
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 190..298
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 337 AA; 34985 MW; 7E97617A84C1DBD4 CRC64;
MNIAIIGAGN IGTAMAALIG SAGGDVTVVA RGHRLDTIRR DGVSLDDRGT LHAAQVTAVT
ALDQVHDAVF LCVKAQDLGA AVAANAAGIG PETLVVPMIN GLPFWYFYGA GGTVPFSDPA
GQLAYHLRPE QVLGAVLLMT VQMTAAGRAV STNTPTLSLA PVVAGADSAA ISRLIDLLCA
SGVRTDLSAD IRQQVLVKLM SNIATNPLSA LTGENLAQIG RELSLRSIAY QLADEVRAWA
DRMLGRSLPP NAWLGDLLLD AGDFPTSMLQ DARAGRVLEL DAICRAPLAL AGEGAMPCLA
ALVAQLDSAD TFPLTGAPRS TAVERLLFLT SLERNSE
//
