ID A0A1H9K2G5_9GAMM Unreviewed; 418 AA.
AC A0A1H9K2G5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=HemY protein {ECO:0000313|EMBL:SEQ93113.1};
GN ORFNames=SAMN03080615_03295 {ECO:0000313|EMBL:SEQ93113.1};
OS Amphritea atlantica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae; Amphritea.
OX NCBI_TaxID=355243 {ECO:0000313|EMBL:SEQ93113.1, ECO:0000313|Proteomes:UP000198749};
RN [1] {ECO:0000313|Proteomes:UP000198749}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18887 {ECO:0000313|Proteomes:UP000198749};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC {ECO:0000256|ARBA:ARBA00002962}.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004744}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}.
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DR EMBL; FOGB01000011; SEQ93113.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9K2G5; -.
DR STRING; 355243.SAMN03080615_03295; -.
DR OrthoDB; 7053339at2; -.
DR UniPathway; UPA00252; -.
DR Proteomes; UP000198749; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR InterPro; IPR010817; HemY_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR NCBIfam; TIGR00540; TPR_hemY_coli; 1.
DR Pfam; PF07219; HemY_N; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 42..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..133
FT /note="HemY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07219"
FT REPEAT 336..369
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 418 AA; 47272 MW; F0B0D8B0BF56807D CRC64;
MKRIFILLLA FMFAGTWIGQ KMIQDSGYTL FAYGQTTVEM SLWVFLVLIV ALFFALHWGI
NLFKRSLKSG THLRLWSGSR KSRIAHDKTL KGLIALSEGN WWKAQRLLSI SADNADLPLI
NYLAAAHAAQ EQGDEKACDE LLQKARASTP EAEITVGINQ AQTQLARGQL EPSLATLLSL
RKKAPKNTYV MKLLRKVYIQ LNDWQSLQAL IPELRKNKAL KPEKLLQTEQ LCYQKLLELS
IVLPDSASSD EKRKALAETW HNMPGQLTQD DQLARHYTRL LVSIGAESKA EPVIRELIKR
NWDNELVNLY GRIEGENPKK QLDTARSWLK DDPLNPDLLL TLGRLSQRNQ HWGKAITYFE
QSLELSPRAE TLSELARLLK NLGETDKMRQ LMDKHLGVIG GGLPALPLPQ KGTKLTAL
//
