ID A0A1H9L4S5_9LACT Unreviewed; 347 AA.
AC A0A1H9L4S5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN ORFNames=SAMN05421767_11720 {ECO:0000313|EMBL:SER06370.1};
OS Granulicatella balaenopterae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Granulicatella.
OX NCBI_TaxID=137733 {ECO:0000313|EMBL:SER06370.1, ECO:0000313|Proteomes:UP000198556};
RN [1] {ECO:0000313|EMBL:SER06370.1, ECO:0000313|Proteomes:UP000198556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15827 {ECO:0000313|EMBL:SER06370.1,
RC ECO:0000313|Proteomes:UP000198556};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; FOGF01000017; SER06370.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9L4S5; -.
DR STRING; 137733.SAMN05421767_11720; -.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000198556; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000198556};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 107..325
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 347 AA; 39891 MW; BC24C5599C49789F CRC64;
MLTDRQLLIL RLIIQLYTET LEPVGSKKLM KAADLPYSSA TIRNEMMKLE ELGYLEKYHT
SSGRVPSNKG YRFFLDYILP QEPAEILPQT KESIRSKLQN PMFEMQELFH MSADILATLT
NYTCISVGPE LSSSRLVGFR LVRLSSTQVM AILVTDKEYV ENKVFSIPSQ VSEDDLERIV
KIMNEELVGL PLSKVIDRLK KDIPLLMKKY IESQILIVNA INEMVNHFEK DRLHVAGKRH
LLNYIDSHSD VEQLKDVYRL MEDSDILHQL VTTNTNGIQI RLGSEMNNPL LEEFSLITAC
YDTPTNDKGV IALLGPVNMP YQKVISIVDS LRQELSLSMN QYYERQR
//
