ID   A0A1H9LND0_9ACTN        Unreviewed;       614 AA.
AC   A0A1H9LND0;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=GABA permease {ECO:0000313|EMBL:SER12936.1};
GN   ORFNames=SAMN05421756_10936 {ECO:0000313|EMBL:SER12936.1};
OS   Microlunatus flavus.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Microlunatus.
OX   NCBI_TaxID=1036181 {ECO:0000313|EMBL:SER12936.1, ECO:0000313|Proteomes:UP000198504};
RN   [1] {ECO:0000313|Proteomes:UP000198504}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.6856 {ECO:0000313|Proteomes:UP000198504};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
CC       {ECO:0000256|ARBA:ARBA00008583}.
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DR   EMBL; FOFA01000009; SER12936.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H9LND0; -.
DR   STRING; 1036181.SAMN05421756_10936; -.
DR   OrthoDB; 5297508at2; -.
DR   Proteomes; UP000198504; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR004840; Amoino_acid_permease_CS.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR43495; GABA PERMEASE; 1.
DR   PANTHER; PTHR43495:SF5; GAMMA-AMINOBUTYRIC ACID PERMEASE; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR   PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        17..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        44..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        151..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        238..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        284..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        356..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        395..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        423..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          16..444
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
SQ   SEQUENCE   614 AA;  65734 MW;  90163C6F43320A83 CRC64;
     MQAAPVELKK GLKQRHLTMI AMGGVIGAGL FVGSGTVISE AGPAAFLSYA ITGVLIILVM
     RMLGEMATAN PSTGSFADYA RQAIGGWAGF SVGWLYWYFW VIVIGFEAVA GAKVIQYWLP
     GVPLWLMSLV LMTLMTATNL FSVGSFGEFE FWFAGIKVAA IVVFLVLGGL FVFGAWPGKD
     LDFSNLTAHD GFLPLGAGAI FSAIVVVIFS MVGAEVATIA AAESPDPGKS IARATNSVIL
     RIAIFFVGSI FLLAVILPWN DAGLAASPYV AAFKVMGIPY ADHIMNAVVL TAVLSCLNSG
     LYTSSRMLFV LAARREAPTA LMEVTGRGVP RNAILASTVV GFLCVIAAAV SPDTVFLFLL
     NSSGAVILFV YLLIAISQIV LRRRSGSEGL TVKMWLFPVL SIVVVVAILA VLVQMGVNEK
     VRPQLVLSLL AWAVVVVLYF LSKKLQGRAP GEQQGRAGAP TPDAPATRVL VLANETVNGA
     ELLDELRRID HERQARYFVC VPANPIDTGQ AMHEGAAFVW DATTAAAQRR LDRTLEILRG
     EGLEADGSLG NYRPLRALAE AVESFHPDRL VVCTLPEDQS AWLRFDVVER AREQHHLPVT
     HVVVTPQPAV AGSR
//