ID   A0A1H9LTA4_9PSEU        Unreviewed;       753 AA.
AC   A0A1H9LTA4;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=cellulase {ECO:0000256|ARBA:ARBA00012601};
DE            EC=3.2.1.4 {ECO:0000256|ARBA:ARBA00012601};
GN   ORFNames=SAMN05216188_10881 {ECO:0000313|EMBL:SER14425.1};
OS   Lentzea xinjiangensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Lentzea.
OX   NCBI_TaxID=402600 {ECO:0000313|EMBL:SER14425.1, ECO:0000313|Proteomes:UP000199352};
RN   [1] {ECO:0000313|Proteomes:UP000199352}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.3525 {ECO:0000313|Proteomes:UP000199352};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endohydrolysis of (1->4)-beta-D-glucosidic linkages in
CC         cellulose, lichenin and cereal beta-D-glucans.; EC=3.2.1.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000966};
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DR   EMBL; FOFR01000008; SER14425.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H9LTA4; -.
DR   STRING; 402600.SAMN05216188_10881; -.
DR   OrthoDB; 9801198at2; -.
DR   Proteomes; UP000199352; Unassembled WGS sequence.
DR   GO; GO:0008810; F:cellulase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030247; F:polysaccharide binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 1.
DR   CDD; cd01833; XynB_like; 1.
DR   Gene3D; 2.60.40.290; -; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR   InterPro; IPR001919; CBD2.
DR   InterPro; IPR008965; CBM2/CBM3_carb-bd_dom_sf.
DR   InterPro; IPR012291; CBM2_carb-bd_dom_sf.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR001547; Glyco_hydro_5.
DR   InterPro; IPR018087; Glyco_hydro_5_CS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013830; SGNH_hydro.
DR   InterPro; IPR036514; SGNH_hydro_sf.
DR   PANTHER; PTHR34142:SF1; CELLULASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR34142; ENDO-BETA-1,4-GLUCANASE A; 1.
DR   Pfam; PF00553; CBM_2; 1.
DR   Pfam; PF00150; Cellulase; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF13472; Lipase_GDSL_2; 1.
DR   SMART; SM00637; CBD_II; 1.
DR   SMART; SM00060; FN3; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49384; Carbohydrate-binding domain; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF52266; SGNH hydrolase; 1.
DR   PROSITE; PS51173; CBM2; 1.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS00659; GLYCOSYL_HYDROL_F5; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023326};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..753
FT                   /note="cellulase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5039275509"
FT   DOMAIN          552..642
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          641..753
FT                   /note="CBM2"
FT                   /evidence="ECO:0000259|PROSITE:PS51173"
FT   REGION          539..562
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   753 AA;  77547 MW;  43991314571146F3 CRC64;
     MTLRFLRAVV TGLLLAACVV IAPAAVSAAA PARIMALGDS ITGSPGCWRA LLWKHLQDTG
     HTGVDFVGSL PAPGCGFAHD GDNEGHGGIL ATNIVRDNLL PGWLSSARPD VVLMHLGTND
     VWSNVPTATI LNAYTTMLGQ MRASNPAVKL VVAQLVPMNP ANCSACGQRV IDLNSAIPGW
     ARANSTAASP VTVVDQWTGF DTAADTTDGV HPNGSTGIQK IESRWYPAVV AALGAQPPAA
     VGLHVEGTKV VEANGSAFVM RGVNHAHVWY QNQTRAFADI KSFGANTVRV VLGSGQRWGP
     TPAAEVSSVI ALCKQSKLIC VLEVHDTTGY GEQSGAASLD QAATYWISVA EALKGQENYV
     IINLGNEPFG NNAEVSATWA SATSGAISRL RGAGLRHLLM ADAPMWGQDW ANIMRDNAAS
     VLNADPQRNT VFSIHMYGVY NTAAKVNAYF DAFRTAGLPL VVGEFGHNHS DGDPDEDTIM
     AQAQARGLGY LGWSWSGNSG DVAYLDMVNS FNPASLTPWG ERFLNGANGV RQTSREATIF
     GGGPGDTRPP SAPGTPAASG VTSTGLTLSW TASTDDVGVT GYEVLRAVGS GSFAQVGSTA
     TTTFADTGLS PSTTYRYQVR ARDAAGNVSA VSGTGTATTS AGGGTGACKV GYSAQNWGGG
     NGFTASVTIT NTGTGAVNGW TLAFSYPSGQ RVTLPGWGAA FTQSGADVTA TNLAWNGTLA
     PNASANIGFN GTHGGSNPAP TSFSLNGSAC TTA
//