ID A0A1H9MA45_9ACTN Unreviewed; 655 AA.
AC A0A1H9MA45;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Acetoacetyl-CoA synthetase {ECO:0000313|EMBL:SER20558.1};
GN ORFNames=SAMN04487983_1012152 {ECO:0000313|EMBL:SER20558.1};
OS Streptomyces sp. yr375.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761906 {ECO:0000313|EMBL:SER20558.1, ECO:0000313|Proteomes:UP000198568};
RN [1] {ECO:0000313|EMBL:SER20558.1, ECO:0000313|Proteomes:UP000198568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR375 {ECO:0000313|EMBL:SER20558.1,
RC ECO:0000313|Proteomes:UP000198568};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FOFF01000012; SER20558.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9MA45; -.
DR STRING; 1761906.SAMN04487983_1012152; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000198568; Unassembled WGS sequence.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000198568}.
FT DOMAIN 41..97
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 99..472
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 539..614
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 655 AA; 72247 MW; 7A392197DBDB7B90 CRC64;
MSTVNPEPLW RPDAQRIAQA QVTKFQTWAA ERYAAPSEGG YPTLHRWSVD ELETFWTAVT
EWFDVRFSTP YARVLGDRSM PGAQWFPGAT LNYAEHALRA AATRPAQPAL LYVDETHEPT
PVTWSELRRQ VGSLAAELRA LGVRPGDRIS AYLPNIPQAV VALLATAAVG GVWTSCAPDF
GARSVLDRFQ QVEPVVLFTV DGYRYGGKEH DRRDVVAELR AELPTLRAVV HIPLLGTEPP
QGALDWSALT AADEEPVFEQ VPFDHPLWVL YSSGTTGLPK AIVQSQGGIL VEHLKQLGLH
CDLGPEDRFF WYTSTGWMMW NFLVSGLLTG TTIVLYDGSP GFPDTGAQWR IAERTGATLY
GTSAAYVMAC RKAEVHPARD FDLSKVQCVA TTGSPLPPDG FRWLHDEVRD DLWIASVSGG
TDVCSCFAGA VPTLPVYTGE LQAPGLGTDL QSWDPDGHPV IDEVGELVVT NPMPSMPVRF
WNDPDGSRYH DSYFDTYPGV WRHGDWITVT SRGSVVIHGR SDSTLNRQGV RMGSADIYEV
VERLPEIKES LVIGIEQPDG GYWMPLFVHL APGAALDEAL LGRIKQALRE QLSPRHVPDE
VIEVPGVPHT LTGKRIEVPV KRLLQGTPLK KAVNPGSIDN LDLLHFYEDL ARKRG
//
