ID A0A1H9P090_9PSEU Unreviewed; 515 AA.
AC A0A1H9P090;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=SAMN04488000_108403 {ECO:0000313|EMBL:SER41003.1};
OS Lentzea albida.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Lentzea.
OX NCBI_TaxID=65499 {ECO:0000313|EMBL:SER41003.1, ECO:0000313|Proteomes:UP000199503};
RN [1] {ECO:0000313|EMBL:SER41003.1, ECO:0000313|Proteomes:UP000199503}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44437 {ECO:0000313|EMBL:SER41003.1,
RC ECO:0000313|Proteomes:UP000199503};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; FOFV01000008; SER41003.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9P090; -.
DR STRING; 65499.SAMN04488000_108403; -.
DR Proteomes; UP000199503; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:SER41003.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SER41003.1}.
FT DOMAIN 15..208
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 257..487
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 515 AA; 53818 MW; FCD84DB91D974B88 CRC64;
MGSALMTRAR KTPGRIAFVG SGPGDTGLLT VRAHDLLTRA ELVVTDPDVP ADVLATVAEG
VEVRPAVGEA ADVAKDLVNE AKNGSTVVRL VAGDPLTLDA VVKEAQAVAK STIPFDVVPG
VPSGTAVPAY AGVALGGVHT EVDVRAVTDW AGLAASPGTL VLHATGSHLA EAASNLVENG
LAPQTPVAVT AEGTGFQQRT VDTTLAAVAA DAGEMGGPLV VTVGAAAAAR SKLSWWESRA
LYGWRVLVPR TKEQAGAMSE RLHSHGAIAV EVPTISVEPP RSPAQMERSV KGLVDGRYQW
VVFTSTNAVR AVWEKFREFG LDARAFSGVK IACVGEATAA KVRSFGIIPE LVPSGEQSSE
GLLNDFPPYD DILDPVDRVL LPRADIATET LAAGLRERGW EIDDVTAYRT VRAAPPPADT
REMIKSGGFD AVCFTSSSTV RNLVGIAGKP HARTLVACIG PQTAETAREF GLRVDVQPEE
ANVPALVDAL AAHAARLRAE GALPPPRKTK RLRRS
//
