ID A0A1H9P5G2_9BACI Unreviewed; 939 AA.
AC A0A1H9P5G2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=3'-5' exonuclease DinG {ECO:0000256|HAMAP-Rule:MF_02206, ECO:0000256|RuleBase:RU364106};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_02206, ECO:0000256|RuleBase:RU364106};
GN Name=dinG {ECO:0000256|HAMAP-Rule:MF_02206,
GN ECO:0000256|RuleBase:RU364106};
GN ORFNames=SAMN05518684_101153 {ECO:0000313|EMBL:SER43428.1};
OS Salipaludibacillus aurantiacus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae.
OX NCBI_TaxID=1601833 {ECO:0000313|EMBL:SER43428.1, ECO:0000313|Proteomes:UP000198571};
RN [1] {ECO:0000313|EMBL:SER43428.1, ECO:0000313|Proteomes:UP000198571}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S9 {ECO:0000313|EMBL:SER43428.1,
RC ECO:0000313|Proteomes:UP000198571};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-5' exonuclease. {ECO:0000256|HAMAP-Rule:MF_02206,
CC ECO:0000256|RuleBase:RU364106}.
CC -!- SIMILARITY: Belongs to the helicase family. DinG subfamily. Type 2 sub-
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_02206,
CC ECO:0000256|RuleBase:RU364106}.
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DR EMBL; FOGT01000001; SER43428.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9P5G2; -.
DR STRING; 1601833.SAMN05518684_101153; -.
DR Proteomes; UP000198571; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd06127; DEDDh; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR HAMAP; MF_02206; DinG_exonucl; 1.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR006310; DinG.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR006054; DnaQ.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR01407; dinG_rel; 1.
DR NCBIfam; TIGR00573; dnaq; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF47; FANCONI ANEMIA GROUP J PROTEIN; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00479; EXOIII; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_02206};
KW Exonuclease {ECO:0000256|HAMAP-Rule:MF_02206,
KW ECO:0000256|RuleBase:RU364106};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:SER43428.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_02206};
KW Nuclease {ECO:0000256|HAMAP-Rule:MF_02206, ECO:0000256|RuleBase:RU364106};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_02206}.
FT DOMAIN 251..526
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT DOMAIN 273..489
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT MOTIF 466..469
FT /note="DEAH box"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02206"
FT BINDING 286..293
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02206"
SQ SEQUENCE 939 AA; 107088 MW; 02981F1346F4C48F CRC64;
MNRFVVLDVE TTGVSFSRGD RIIQLAYSVV ENEQIIHRYS TYINPERSIP PFIKSLTNIH
EKHVSEAPVF SEIAPGLLEE LEGAYFVAHN VEFDLKFIND ELVNAGYVPF EGPVIDTVEL
SRIVFPTQDS FKLSQLTESF EMDHFEPHRA DSDAEATALL LIEIFQRLSA LPLLTLQQLE
KLQGRLKSDT GSILREWIEL SKSSPEDFPE IDAFRGLAVK EPAGYSGEVT AGAVPESVTD
FLHSTLENVN FMKEKIPSYE RREGQMDMIR FIDEVFKNDS IGLIEAGTGT GKTLGYLIPA
ALYSRTESGP VVISTETVQL QDQIVSKELP ALQQLLPFKI KAALLKGRSH YLCLQKFENI
LINDPIDSYD RTLSKAQILV WLTETDTGDV EELSLASGNS RFWEEVASDP RSCSTPQCPW
FSRCFYQRAR KQSKKADLII TNHSLLFTDM AAEHQILPSY STLIVDEAHH LEDSATRQFG
GKLDYLTMTQ LLNDLVREKE GWVPENIWRL MGSGLKENSK EFFELSGQFK QEWNDLFLLL
NQYAGKGMAG KNETGRLSKI INSADKFWDT VRETAGRCDN LFKALLKKLN YIIRETDLLL
EDKETSDHHQ REAEWMAALL FKIEEQYLSF HELILNHEDS SVYWLELETK GPKQSIAVHG
SPIQIADKLA DNFFAKKDRV ILTSATLTVN NQFKYMIHRL GLEDFQVETK QVDSPFSWDK
QVSFMVPEDM PLIQEAGEEA YIEAAALQIY RIAHVTKGKM LVLFTSYDML RKTYFQLKKM
LDESFMLIAQ GIQTKSRSKL TKNFQQFDQA ILFGTSSFWE GVDIPGSDLS AIVMARLPFS
PPNDPVFKKR SDTLKEEGHS PFMKLALPQA VIRFKQGFGR LIRSSTDRGI VVVLDRRLTT
TRYGKSFTRS LPDIPMIEEP MSEMEERIAD WFNQPLIDK
//
