ID A0A1H9PPI6_9LACT Unreviewed; 833 AA.
AC A0A1H9PPI6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=DNA translocase FtsK {ECO:0000256|ARBA:ARBA00020887};
GN ORFNames=SAMN05421767_1662 {ECO:0000313|EMBL:SER50112.1};
OS Granulicatella balaenopterae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Granulicatella.
OX NCBI_TaxID=137733 {ECO:0000313|EMBL:SER50112.1, ECO:0000313|Proteomes:UP000198556};
RN [1] {ECO:0000313|EMBL:SER50112.1, ECO:0000313|Proteomes:UP000198556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15827 {ECO:0000313|EMBL:SER50112.1,
RC ECO:0000313|Proteomes:UP000198556};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA.
CC {ECO:0000256|ARBA:ARBA00025923}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
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DR EMBL; FOGF01000066; SER50112.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9PPI6; -.
DR STRING; 137733.SAMN05421767_1662; -.
DR Proteomes; UP000198556; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000198556};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 477..678
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 222..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..828
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 499..506
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 833 AA; 93264 MW; 88CF062532571E0C CRC64;
MSKKVKKKTS NKKKKKTNKE SNISIEVIGI IIIFISVIGV FRLGYIGLML TNLFRFFVGN
STIIAFMIFI MYALYFIVKG KELEIPRNIF WSFLLAYITW LLMSDAMVFQ DIWQQNETPI
GATLNNFASD FQQGQIETDM AGGIIGALLY TGSHFLFAQM GTYAVIIMLA ISSVLIFLQI
GFSEVMVKVR ESLLDLADVF VREDNGDYQY EEDEKYIEAE KERKAKKKNK TKSEKKTPLK
NVSSVGQSLK TRSKQFLDVI FDDEELEADK ANDGQQLDYE PELPIMDSFS DLEPFKDTYI
PVEPPYPDFN ESEAHPAIKD NRNSEDASED TELGELNMGG TPEDDHYELP PLSLLNPVPV
NDQTSEKNTV RKNMKILEQT FESFGVDCKV MDEPLLGPAV TKYEIKPAIG VKVSKIVNLS
DDIALALAAK DIRIEAPIPG KPYVGIEVPN SKTSFVSFSD VIQASLLSPN KLDVPLGRDI
SGNSRLCDLT RMPHMLIAGS TGSGKSVCIN GIITSILMKT KPHEVKLMMI DPKMVELNVY
NGIPHLLTPV VTNPKKAAQA LQKVVAEMEK RYELFASMGM RNIDGYNQHV DQYNQEMGQN
NPKLPYIVVI VDELADLMMV ASNEVEDAII RLAQMARAAG IHMILATQRP SVDVITGIIK
ANVPSRIAFA VSSGTDSRTI IDANGAEKLL GRGDMLFMPM GENKPIRVQG AYITDEEVER
VVEFVKNQQE VEYVEEMMPT DVPKQMDGEP EDELFGEALD LLKDLETVST SFLQRKFRIG
YNRAARMIDE LEARGYIGPS EGSKPRKVNI QDFSEPEEKN ENAETLVEST KID
//
