ID A0A1H9RSP2_9CORY Unreviewed; 523 AA.
AC A0A1H9RSP2;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Endonuclease G {ECO:0000313|EMBL:SER75667.1};
GN ORFNames=SAMN05661109_00899 {ECO:0000313|EMBL:SER75667.1};
OS Corynebacterium cystitidis DSM 20524.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1121357 {ECO:0000313|EMBL:SER75667.1, ECO:0000313|Proteomes:UP000198929};
RN [1] {ECO:0000313|EMBL:SER75667.1, ECO:0000313|Proteomes:UP000198929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20524 {ECO:0000313|EMBL:SER75667.1,
RC ECO:0000313|Proteomes:UP000198929};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FOGQ01000003; SER75667.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9RSP2; -.
DR STRING; 1121357.SAMN05661109_00899; -.
DR Proteomes; UP000198929; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR020821; Extracellular_endonuc_su_A.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR040255; Non-specific_endonuclease.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR PANTHER; PTHR13966:SF5; ENDONUCLEASE G, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13966; ENDONUCLEASE RELATED; 1.
DR Pfam; PF01223; Endonuclease_NS; 1.
DR SMART; SM00892; Endonuclease_NS; 1.
DR SMART; SM00477; NUC; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:SER75667.1};
KW Hydrolase {ECO:0000313|EMBL:SER75667.1};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR640255-2};
KW Nuclease {ECO:0000313|EMBL:SER75667.1}.
FT DOMAIN 372..523
FT /note="DNA/RNA non-specific endonuclease"
FT /evidence="ECO:0000259|SMART:SM00892"
FT DOMAIN 373..520
FT /note="Extracellular Endonuclease subunit A"
FT /evidence="ECO:0000259|SMART:SM00477"
FT REGION 261..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 435
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR640255-1"
FT BINDING 471
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR640255-2"
SQ SEQUENCE 523 AA; 57622 MW; 9F2AF39BC1B35B88 CRC64;
MAYMAFSTHP KYRAWIRRHG RHYLKDPNIT SVGVGYKIVG GKRSDEICIQ FTVKRKWDES
HLEHVSTHIP EHVEHDGVQI ITDVVERTYE LAYQVVPEAF NDHRRSYQDP IRPGISISHP
LVSAGTLGAI VYDKATGKPA ALSNWHVLHG PDGSIGDVAL QPGTHDDNSN ADNRFGTLLS
SHIGAAGDGA LASIDSRDVT TDILDLDVTP TEIADPELGD QVVKSGRTTG VSHGVVTRID
TLVSIDYGDG VGEQTIGCFE IEPDPRRDDE TNHLSDGGDS GATWLFKTGN GRPAPIMGGL
HFAGSDTPDT ETALACYASS IRDKLGFTLA SAVAEKSRGF DPHFLSTPVD VPGMSQELND
DAVVLNGSTT IDYTHFSLAQ SRERKFARWV AWNIDGGRMK KLGRKGIKFR YDDRFDHALQ
AGNDLYKDND LDRGHIARRA DLTWGPQEEA AQANRDSFTY TNIAPQMNTF NQSGRGGVWG
QLEDAVYVEV QVDDLRVSVI GGPVFKDTDR KYRGYLIPRE FFK
//
