ID   A0A1H9RU73_9ACTN        Unreviewed;       537 AA.
AC   A0A1H9RU73;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Uroporphyrinogen III methyltransferase / synthase {ECO:0000313|EMBL:SER76098.1};
GN   ORFNames=SAMN05443377_10936 {ECO:0000313|EMBL:SER76098.1};
OS   Propionibacterium cyclohexanicum.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Propionibacterium.
OX   NCBI_TaxID=64702 {ECO:0000313|EMBL:SER76098.1, ECO:0000313|Proteomes:UP000198815};
RN   [1] {ECO:0000313|EMBL:SER76098.1, ECO:0000313|Proteomes:UP000198815}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16859 {ECO:0000313|EMBL:SER76098.1,
RC   ECO:0000313|Proteomes:UP000198815};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005879}.
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DR   EMBL; FOGZ01000009; SER76098.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H9RU73; -.
DR   STRING; 64702.SAMN05443377_10936; -.
DR   OrthoDB; 9815856at2; -.
DR   Proteomes; UP000198815; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR   PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   Pfam; PF00590; TP_methylase; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
DR   SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:SER76098.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198815};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SER76098.1}.
FT   DOMAIN          26..221
FT                   /note="Tetrapyrrole methylase"
FT                   /evidence="ECO:0000259|Pfam:PF00590"
FT   DOMAIN          273..499
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
FT   REGION          517..537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   537 AA;  56696 MW;  9FAB8A17110B58D6 CRC64;
     MSQLNDETIS ETEEFSGAVT ATTGGRIAFI GVDPNSADFL TLAGARALRE ADLLITTKPL
     RAVLDDAGVE LPTREDTHFL AELPDVVDFE VKSASEGRSV ARLVAGDPLI EAGIAGEAQA
     CARAGCPIDI VPGVPMLTAT PTLAGVSFPG HAVQLVAVPD DAHMVDLPAQ GSVTLSCGPS
     QLPGVVAGAV QAGRAKDEPV LVTTGAATPR QHSVLATLGK VEKVAREQAV DDEPIFLVLG
     PAAERDEALD WYESKPLFGW RVLVPRTGAD CRRLVERLRL HGAVSEEVAT ISVEPPRNPQ
     QLDKAVRGMV DGRYEWVVFT SAHAVRAVFG KLEEYGLDSR ALSGLRIATV GADTASALHT
     WGIAPDLSPS TVQTVAGLAG EFPAYDEVLD PINKVFVPRA DIATEPLAVG LTELGWEVDD
     VTAYRTVRAA PPPLETREAI KSGRFDAVAF TSSTTVRNLV GIAGKPHAQT LVVAIGPATV
     EACEEHGLRV DAMAPRPGQI ELADALAEMA RRRRDALAAA GQTVTRPSAK RRRRASH
//