ID A0A1H9SRU1_9BURK Unreviewed; 320 AA.
AC A0A1H9SRU1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Glycerate dehydrogenase {ECO:0000313|EMBL:SER87686.1};
GN ORFNames=SAMN02982919_03209 {ECO:0000313|EMBL:SER87686.1};
OS Giesbergeria anulus.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Giesbergeria.
OX NCBI_TaxID=180197 {ECO:0000313|EMBL:SER87686.1, ECO:0000313|Proteomes:UP000199766};
RN [1] {ECO:0000313|EMBL:SER87686.1, ECO:0000313|Proteomes:UP000199766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35958 {ECO:0000313|EMBL:SER87686.1,
RC ECO:0000313|Proteomes:UP000199766};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; FOGD01000022; SER87686.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9SRU1; -.
DR STRING; 180197.SAMN02982919_03209; -.
DR OrthoDB; 9805416at2; -.
DR Proteomes; UP000199766; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd12162; 2-Hacid_dh_4; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43761:SF1; 2-HACID_DH DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000199766}.
FT DOMAIN 25..313
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 106..286
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 320 AA; 34609 MW; B5BEB1EADED3AD3E CRC64;
MKIVFLDRET LSPQTVLRSP SFPHELKLHS RTAPTEVSTR ISDAHIVVVN KVKLSAQDIA
AAPNLRMIAI AATGTDNVDL VACQARGIVV SNIRNYAKHT VPEHTFALIF ALRRSVAAYL
QSVRDGRWQQ AQQFCFFDHP IRDLTASTLG IIGDGVLGQA VASIGRALGL RVLFTGHKGR
TGQGNLYTPF EDMLRQADII TLHCPLNAQT RNMIGPDEFA AMARRPLLIN TARGGLVDEA
AVGPALDAGH ISGAAFDVAS VEPPPPDHPF MALLDRPNFI LTPHVAWASD EAMQGLADQL
IDNIEGFFHG APVNVMEPAP
//
