ID A0A1H9TTY0_9BACI Unreviewed; 713 AA.
AC A0A1H9TTY0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=SAMN05518872_103147 {ECO:0000313|EMBL:SES00441.1};
OS Psychrobacillus sp. OK032.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Psychrobacillus.
OX NCBI_TaxID=1884358 {ECO:0000313|EMBL:SES00441.1, ECO:0000313|Proteomes:UP000199084};
RN [1] {ECO:0000313|EMBL:SES00441.1, ECO:0000313|Proteomes:UP000199084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OK032 {ECO:0000313|EMBL:SES00441.1,
RC ECO:0000313|Proteomes:UP000199084};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; FOGY01000003; SES00441.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9TTY0; -.
DR STRING; 1884358.SAMN05518872_103147; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000199084; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:SES00441.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 2..129
FT /note="Toprim"
FT /evidence="ECO:0000259|SMART:SM00493"
FT DOMAIN 130..225
FT /note="DNA topoisomerase type IA"
FT /evidence="ECO:0000259|SMART:SM00436"
FT DOMAIN 271..550
FT /note="DNA topoisomerase type IA DNA-binding"
FT /evidence="ECO:0000259|SMART:SM00437"
SQ SEQUENCE 713 AA; 80581 MW; 98D1F8C1C913AE84 CRC64;
MKPVILAEKP SQAKAYADAF SVKRHEGFLE ILPCPIFPEG AYITWGIGHL VELKEPKAYD
PKWDKWSLNS LPILPDRYEF QVAKGKFKQF TIVKKLIRAT DTIINACDVD REGSNIFYSI
YYQTGARGKT IKRLWINSLE VDEVRKGFAN LQDNRKDLLL YEEAKARQIS DWLVGMNGSR
LYSLLLQSQG IREVFPIGRV QSPTIYLIYQ RQLEIENFVS EPFFEIEAIF TAEHGVYKGK
AKAKEPKREI IQALLAKHAI QPNSPGVITS VEKLDKRMPP PQLHSLSTLQ ATANRLWKTS
PADVLKTMQG LYEKKLVTYP RTDSRFITTS EFSYLAGQVT EYQKLIGHPF PVASLVPKKR
YVDNSKVQEH HAIIPTKKLP TQAKLAGLSS IERNLYEEIV RTTLAMFHTD YLYTETKVTT
DINGLPFFTT GKTERDKGWK ALLVRSSKET EKDEPTLPPL FEQEKVESNI GIKEGKTQPP
KPYTEGQLIA MMKTCGKLVE DKNETDILKE VEGLGTEATR SGIIETIKRH GYIDVTKNIV
SITDKGRVLC QAIEGNLLAS PSMTAKWETY LRKIGNGEGS QERFLGSIAK FIHSLLQEVP
NQLKTKNIDI QLVPSKKSNA KYKQEPIAPC PKCNQGSIVA RKNFYGCTNY KNGCTQTFNG
FFLKKKITPS QIKLLCTKGK TNVIKGFVAE NGQTFNASLS FIEGKVKLDF AKE
//
