ID   A0A1H9U4J1_9ACTN        Unreviewed;       223 AA.
AC   A0A1H9U4J1;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=5-formyltetrahydrofolate cyclo-ligase {ECO:0000313|EMBL:SES04084.1};
GN   ORFNames=SAMN05443377_1387 {ECO:0000313|EMBL:SES04084.1};
OS   Propionibacterium cyclohexanicum.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Propionibacteriaceae; Propionibacterium.
OX   NCBI_TaxID=64702 {ECO:0000313|EMBL:SES04084.1, ECO:0000313|Proteomes:UP000198815};
RN   [1] {ECO:0000313|EMBL:SES04084.1, ECO:0000313|Proteomes:UP000198815}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16859 {ECO:0000313|EMBL:SES04084.1,
RC   ECO:0000313|Proteomes:UP000198815};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 5-formyltetrahydrofolate cyclo-ligase
CC       family. {ECO:0000256|ARBA:ARBA00010638}.
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DR   EMBL; FOGZ01000038; SES04084.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1H9U4J1; -.
DR   STRING; 64702.SAMN05443377_1387; -.
DR   OrthoDB; 3242798at2; -.
DR   Proteomes; UP000198815; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.10420; NagB/RpiA/CoA transferase-like; 1.
DR   InterPro; IPR002698; FTHF_cligase.
DR   InterPro; IPR024185; FTHF_cligase-like_sf.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR23407:SF1; 5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE; 1.
DR   PANTHER; PTHR23407; ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE; 1.
DR   Pfam; PF01812; 5-FTHF_cyc-lig; 1.
DR   PIRSF; PIRSF006806; FTHF_cligase; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR006806-
KW   1}; Ligase {ECO:0000313|EMBL:SES04084.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRSR:PIRSR006806-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000198815}.
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         26..30
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006806-1"
FT   BINDING         75
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006806-1"
FT   BINDING         80
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006806-1"
SQ   SEQUENCE   223 AA;  23707 MW;  9CDDDE0EF5129773 CRC64;
     MPAPPSSPGG AAESAPTTST DPDEVKKALR RTSASARRVL AEDTRRRNDE SRTTRVLSLV
     REQWPAHKAV IGCYLSISPE PDTLALVALL QSMGHEILAP VLSRRAGTGA PRPVAWARYE
     GPASLTPGFH AIPEPKGEVL RADALLRADL VIASGLAGGL DGSRVGTGGG WFDRALTSLP
     DGAPVWLLLN DSEVHASIPQ QAHDHPISTI VTPTRTLRTT MRE
//