ID A0A1H9VBH7_9BACI Unreviewed; 680 AA.
AC A0A1H9VBH7;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN ORFNames=SAMN05518872_105224 {ECO:0000313|EMBL:SES19042.1};
OS Psychrobacillus sp. OK032.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Psychrobacillus.
OX NCBI_TaxID=1884358 {ECO:0000313|EMBL:SES19042.1, ECO:0000313|Proteomes:UP000199084};
RN [1] {ECO:0000313|EMBL:SES19042.1, ECO:0000313|Proteomes:UP000199084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OK032 {ECO:0000313|EMBL:SES19042.1,
RC ECO:0000313|Proteomes:UP000199084};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC -!- SIMILARITY: Belongs to the peptidase S9A family.
CC {ECO:0000256|ARBA:ARBA00005228}.
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DR EMBL; FOGY01000005; SES19042.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9VBH7; -.
DR OrthoDB; 9801421at2; -.
DR Proteomes; UP000199084; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR023302; Pept_S9A_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR Pfam; PF02897; Peptidase_S9_N; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 10..401
FT /note="Peptidase S9A N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02897"
FT DOMAIN 464..678
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 680 AA; 77847 MW; 6630B394C52FFF14 CRC64;
MQTKNEKGIV VDNYHGTLVE DPFRWLEDDK SIETKNWEDN QNKQTHAYFS KIQNRVTIKD
KLMEHWNYEK YFIPQKEGSY YYYHKNDGLQ NQPVFYRAHA LTDATPEVII DPNALNSDGT
TALTNISFNK EGTLMAYAIS ENGSDWQEIK IRNMESGFEY PEIINRCKFS SLAWIENGTG
FYYSRFPDQG TVELVDESNY NRLYFHIVNT PQSEDKLIHE RPDDKELAFR PIVSDDYKYL
LLESWKGTEN KSRLYYRAIE SDDAFIPLAD AGDANYSFIG NNGTTFYIYT NKDAPNGKIV
AINLNEPQMN QWKETIPEQQ DVMSFIKLID DQIAITYMHH AKDQIKLYDL DGVFDRILDL
PDMITVTNIS TNKKEKEMFI SYTSYLTPTT VVRYDFHTKS LDTVFSSKVS LDSSRFETTQ
VFYPSTDGTN IPMFITHKKG IQLTADHPVL LYGYGGFNIS MTPSYSASNA MFIEDGGIYA
VANIRGGGEY GEDWHQAGTF ERKQQVFDDF IAAAEWLISS DYTNSSKLAI MGGSNGGLLV
SACMNQRPEL YNAVICQVPV TDMLRYQHFT VGRFWTSEFG NAEENAEHFK TIYAYSPLHN
ISPNRNYPAT LITTADTDDR VVPLHAKKYA ATLQEAKIGE APILLRIEKD AGHGLGKPTS
KIIEEHTDIY TFIYKFLGMN
//
