ID A0A1H9VHR1_9PSEU Unreviewed; 425 AA.
AC A0A1H9VHR1;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase {ECO:0000256|ARBA:ARBA00012519};
DE EC=2.7.7.70 {ECO:0000256|ARBA:ARBA00012519};
GN ORFNames=SAMN05216188_12664 {ECO:0000313|EMBL:SES21014.1};
OS Lentzea xinjiangensis.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Lentzea.
OX NCBI_TaxID=402600 {ECO:0000313|EMBL:SES21014.1, ECO:0000313|Proteomes:UP000199352};
RN [1] {ECO:0000313|Proteomes:UP000199352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.3525 {ECO:0000313|Proteomes:UP000199352};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-
CC D-glycero-beta-D-manno-heptose + diphosphate; Xref=Rhea:RHEA:27465,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:59967, ChEBI:CHEBI:61593; EC=2.7.7.70;
CC Evidence={ECO:0000256|ARBA:ARBA00000534};
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DR EMBL; FOFR01000026; SES21014.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1H9VHR1; -.
DR STRING; 402600.SAMN05216188_12664; -.
DR OrthoDB; 9802794at2; -.
DR Proteomes; UP000199352; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR011914; RfaE_dom_II.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR NCBIfam; TIGR02199; rfaE_dom_II; 1.
DR PANTHER; PTHR43793:SF2; BIFUNCTIONAL PROTEIN HLDE; 1.
DR PANTHER; PTHR43793; FAD SYNTHASE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR Pfam; PF00294; PfkB; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 161..275
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
FT DOMAIN 298..408
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 425 AA; 44257 MW; DCC0A78754B5AD5A CRC64;
MKLVVVGDAL LDVDVEGTVD RLCPDAPAPV LDVVAEHPRA GGAALAATMA ARDGVDVTLV
SALSDDSDGE RLRSLVGVPG VFGHVDSVPV KTRLRSAGTS LARMDRGGSS TPPRVTDDML
DVVLSADVVL ASDYGRGLLR DERLRSVLTR VPVVWDPHPR GPAPVPGARL VTPNLSEATA
FSGTSDPDEA ARTLLANWQA RAVVVTMGGD GAVLHCGGTP IAVPAPAVAV ADPCGAGDRF
AVTAAVRLAG GAAPDDAVAD AVAAAAEFLA RGGVSGMRAP LPSTVDEVRR RGGVVVATGG
CFDVLHTGHV RMLAAARALG DCLVVCLNSD QSVRRLKGEG RPVNRQEERI EVLRALESVD
DVIVFGEDTP ENVLGRLRPD VWVKGGDYTA ELLPENAVVR RWGGRTVVVP YHRGRSTTEI
LARRG
//
