ID A0A1H9VN89_9ACTN Unreviewed; 1897 AA.
AC A0A1H9VN89;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Ketoacyl-synthetase C-terminal extension {ECO:0000313|EMBL:SES22663.1};
GN ORFNames=SAMN04487983_10372 {ECO:0000313|EMBL:SES22663.1};
OS Streptomyces sp. yr375.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1761906 {ECO:0000313|EMBL:SES22663.1, ECO:0000313|Proteomes:UP000198568};
RN [1] {ECO:0000313|EMBL:SES22663.1, ECO:0000313|Proteomes:UP000198568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YR375 {ECO:0000313|EMBL:SES22663.1,
RC ECO:0000313|Proteomes:UP000198568};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FOFF01000037; SES22663.1; -; Genomic_DNA.
DR STRING; 1761906.SAMN04487983_10372; -.
DR Proteomes; UP000198568; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000198568};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 33..459
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1537..1619
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 463..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1897 AA; 195963 MW; 8D530D027E757A4F CRC64;
MSDVTRLRDY LRKVTVDLHE TRQRLREYEQ RDAEPVAVVG MACRFPGGIA SPDDLWEVVA
AGHDVMSAFP GNRGWPLDRL YDPDPDRPGT TYVKEAGFLH DVADFDATFF GISPREALAM
DPQQRLLLET SWEALEHAGI DPLSLRGSQT GVFVGSGAQD YGMLAAQAAD DLEGFLLTGN
AISVLSGRVS YTLGLEGPAL SVDTACSASL VALHLACQSL ARGECSLALA GGASVLSTPA
GFVELSRQRG LAPDGRAKAF AEAADGTAWS EGAGVLVVER LSDARRNGHR VLAVVRGSAV
NQDGASNGLT APNGPSQERV IRAALADADL TAADIDAVEA HGTGTALGDP IEANALLATY
GRNRPADRPL WLGSLKSNLG HSGAAAGVGG VIKMVMALRG DHLPRTLHVD APTSKVDFSA
GNVALLTEPQ PWPQTGRPRR AGVSAFGISG TNAHVLLEQA PEFITPDPDT PDGRPTSPGT
TAPAGTAVPS ARASTTAPAA TTAPAGATAS SAPADTTAPA GTTAPAGTTA PAGTTAPAGT
TAPAGTTAPA GTAAPAATTA PAGTTVPTAP PAPVPIAVSG RSREALRAQG DRLLPLVQRG
TPLPDLAAAL LRHRSALEHR AVVVADDADT VAAGLRALAE GRPHDAVVSG TAVPTDRVVF
VFPGQGSQWA GMAVELLDSA PVFAAHLAEC DSAARAFVDW SIADVLRGAP GAPSMEPIEI
LQPVLFAVMV SLAELWRSYG LTPAAVVGSS QGEIAAAYTA GALSLHDALK IVVLRSQLFA
DELRGNGAVV SVAAPEQQVR ARLAAQGDDT LHIGGVNGPN AVTVVGPPAG LDRFVAEATA
DGLRARLVGS TVASHCDQVD PLRERILDMF ADIRPTATTV PFCSTVTGEF TDPATLGAPY
WFDNARRPVA FDPAVRTLLA AGLRFFVEVS PHPVLVTAVQ DIAEDAGADA AVVGSLRRDQ
GGLDRFLRSV ADAHTRGAPV DLGVALAGRD TAWVDLPTYP FQRQRYWPEA DATAVSDPAA
PADAVESGFW EAVENADLAG LTETLELDAE PLAAVLPALS AWRRQRREQS VVDSWRYALD
WRPVPDPASP RLSGDWLVAV PPGHTGPEPD ALARHGARVI RVEVTADPSA PEALRTALAG
ARPDGVLALL DWPAAVSLVR ALLELGVAAP LWFTTTEAVA LDAAPDGDPD RAALWGLAPT
VSLEHPDLTG GIVDLPARPD ERALTRWCAA LSGRTGEEQL AVRPAGLFAR RLVRSPLTAP
TGAAWRPTGT TLVTGADTAV GAAVARSLAA AGAPALLLTV DPGGDAPAED ATAELRELGV
EVRTVACDLT DRAAVAALLA ELPAGQPLTA VVHTAVPLDE TPLSTLDGAA ASAPRRGVTA
AWHLHELTRD APLTAFVLFS SISGTFGGIG QAAYAAATAG LDALAEHRAA AGLPALSVAW
APWADPADTT GVAATRRERL ASRGIGVLDE HRALAALGDA LTAGDTRLLL AEVDWPRFRG
AYTLTGPRPL IAEFTPDRGR RTATGPATPV VGELAALPAA ERLGVLLAAI TGQAAAVLGF
PDSSAIDPAR RLLEHGFDSL TTLELRNRLT AATGVRLTAA TLFEHDTPEA LARHLQGELG
PDPVATAVAE PGLFAAFQHR AAEAGKTGEF VELLAAAAKL RTTFGSAEEA GALPEPVELT
AHDEGPVLVC LPTVLATSGP HQYARFAAGL RERRAVSAIA LPGYLDGEPL PADRPAAIEA
ATRQVLAAAG ERPVVLVGYS SGGLLADGVA ARLAALGRPA AALVLIDTFV FGAELPTSGA
ALFEQMFARL ADSGAATDAR LTAMGGYLRL LTDWEPGACP TPILVARATE PLAGFDRPPA
TWAYPHDAVE LVGDHFTVLE EHADRTAQAV HEWLEKR
//
