ID A0A1H9VZX8_9PSEU Unreviewed; 1501 AA.
AC A0A1H9VZX8;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Subtilase family protein {ECO:0000313|EMBL:SES27256.1};
GN ORFNames=SAMN04488000_12030 {ECO:0000313|EMBL:SES27256.1};
OS Lentzea albida.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Lentzea.
OX NCBI_TaxID=65499 {ECO:0000313|EMBL:SES27256.1, ECO:0000313|Proteomes:UP000199503};
RN [1] {ECO:0000313|EMBL:SES27256.1, ECO:0000313|Proteomes:UP000199503}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44437 {ECO:0000313|EMBL:SES27256.1,
RC ECO:0000313|Proteomes:UP000199503};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240}.
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DR EMBL; FOFV01000020; SES27256.1; -; Genomic_DNA.
DR STRING; 65499.SAMN04488000_12030; -.
DR OrthoDB; 3751446at2; -.
DR Proteomes; UP000199503; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00161; RICIN; 4.
DR Gene3D; 2.80.10.50; -; 3.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR InterPro; IPR010496; 3-keto-disaccharide_hydrolase.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR Pfam; PF06439; 3keto-disac_hyd; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF00652; Ricin_B_lectin; 3.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00458; RICIN; 3.
DR SUPFAM; SSF50370; Ricin B-like lectins; 3.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 3.
DR PROSITE; PS51892; SUBTILASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1501
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011755374"
FT DOMAIN 1125..1244
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
FT DOMAIN 1248..1371
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
FT DOMAIN 1377..1497
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
FT REGION 342..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 150
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 188
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 474
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1501 AA; 155677 MW; 1E1313DBC61BD8AF CRC64;
MRRTRRVAVA AACLTLGVAG AVSPVQAAPG NGARPDVVNS ARHVVGSQDV AKDAQGRMIV
YVEGAQESSL RAAVAKAGGV VADADAGRVK AVVPQDKLDV VASQAGVTEV RLPDRAVPMG
VTSEGVVPSR ANEWISAGKT GAGVKVGIID VGFGDLAASQ AAGELPATGP QLAYRDAGCL
DATTKSVHGT NVAETVHDMA PGAELYLACV EDSVSFSAAA DWMDQQGVKI ISSAVGFLSP
SGGRGDGSGP QDSPADVVKR SRAKGVLWNV AAGNLARTHF AGTPVVTGDT RWVKFRNDTQ
FNQIILSANQ SATISIRWDA WPTTNEDLDL YVMDQMIAPD APNAPAPRKV SLRSQKDAQG
GLSPTEEVQI SNTAASSRPF YVYVKNNNAR FTTPFELFVA GPEQIQYWTE AGSITEPATS
PHVLAVGATQ PGSGQVEDFS GRGPTIDGRT KPDIIGFDRT STSMWPAPDF RGTSAATAHV
AGAAALLKSA NPALDATQLQ SALQGRAVRP ANADPNTWGS GVLNVGAATN VPTAPAGSKY
TADPVPTRTV AGQVFAAGET RTIPFSSLPS ESTAVAITVS VRANQDSIGE FGLEIAQGDP
AVLGGKVPTI YGRGENSWTW TTMTLFAPLD GARSIKMRNR GNGPVVVVVE RLGYFHPNGV
STFTALKEPA RVLDTRGFPV VTGGSTRKTP LIGANDTEKT VDVPVRGVGQ VPTTATSVVV
NLTGFEATQV QFLVVHAGGT SVPVTTSLVL GPGERRSNLV VVPIGADGKI RLTNTSSGYT
AGAALDVVGW FADGDSGARY VPFGDVGRVA DTATGNGVPK ALIGHGQSAA FQVTGTAGIP
DSATTAAMVL TGRDDNLGTE LSAVSKEVGW LPASQVSTRK AEPASGLALV PLGSSGEVRV
RNERGQTKLS ADVTGYFVGS AKVTGPASDT CVTAADEPGF TSILDGRSES DLAGWRSTGT
KMTADRCEAV TANTSDVNWY TAHTYNSDYT LKVDWKATTN NSDSGVFVGI TNPGTNAAAP
GQSGYEINIG PTGATGTMQT GGVVGIKPPL TTTAVKPVNQ WNTFKFVFRW NTVTVYLNDT
LVNEHGFSDA TAASRNTFIG LQNDNTGDPV RFRNVRIKRD TPVLSGVVKN SGGRCLDMFN
ADPNQSVVEL FTCHGGFAQV WTMHGGLVLA GGRCLRAAGT TDGTEAVLGG CAGDDFQQWT
LRGDNRLVHR QSGRCLTPRS NTDLARLELR ACNLGDASQT WVVPEANGGR VGQIVAPVGK
CIDIFNSDVT QNRIGVHPCH GGLNQSWVMT GDGTVRGSGK CLNIASNTPG EGSAVNVADC
NGSQHQQWLA QQEGTLVNPL TGRCLASAGG EFAPLLISTC NGTPAQSFRL SSQVVSVGQV
VGLATKCVDV FGGTTSGKVN LHTCVGSSAH NWWSTGDGTL RALGSCLDIQ STANAALTVL
AGCRGDGGQI WSARHDGTIV NPMSNRCLDV FGALPDDGTQ IIIGDCHGGP NQRWATPVNP
S
//
