ID   A0A1H9W008_9PSEU        Unreviewed;      2703 AA.
AC   A0A1H9W008;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Nonribosomal peptide synthetase protein BlmVI {ECO:0000313|EMBL:SES27119.1};
GN   ORFNames=SAMN05216188_12944 {ECO:0000313|EMBL:SES27119.1};
OS   Lentzea xinjiangensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Lentzea.
OX   NCBI_TaxID=402600 {ECO:0000313|EMBL:SES27119.1, ECO:0000313|Proteomes:UP000199352};
RN   [1] {ECO:0000313|Proteomes:UP000199352}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 4.3525 {ECO:0000313|Proteomes:UP000199352};
RA   Varghese N., Submissions S.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; FOFR01000029; SES27119.1; -; Genomic_DNA.
DR   STRING; 402600.SAMN05216188_12944; -.
DR   OrthoDB; 3671040at2; -.
DR   Proteomes; UP000199352; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd05931; FAAL; 1.
DR   CDD; cd19531; LCL_NRPS-like; 1.
DR   Gene3D; 3.30.300.30; -; 3.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR040097; FAAL/FAAC.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 3.
DR   Pfam; PF13193; AMP-binding_C; 2.
DR   Pfam; PF00668; Condensation; 2.
DR   Pfam; PF00550; PP-binding; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE   4: Predicted;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          600..674
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1646..1720
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1628..1651
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2163..2183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1630..1651
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2703 AA;  289254 MW;  0353A0B50E8352DE CRC64;
     MSTQTGASRA SGHADHRHDT IVDIARRHAG TNPGRPAYLF LADGVTESTS HDFNGIDRRA
     RAVAAELAAR GCRGERVLIA YPSSMEYVES FLGCLYAGAV AVPCDSGRGG AGAERLAAIR
     TDATPVLVLC DPANSAESLA GLPRLHVRDV PDSAAGEWEH PGAGQDAVAF LQYTSGSTRT
     PSGVLVTHAN ILANEHAIQV ACGNDRDANF VGWLPLFHDM GLIANVLQPL YLGSRSVLMP
     PEAFLRSPLA WLRAVERYSA RVSGGPNFAY ELCLARISER DRAELDLSGW AVAYNGAEPV
     RHETLRRFTE GFRSAGFAPT AHFPCYGLAE ATLIVASTPA TEAPTTVRAD PAALRRGELT
     PVAANEPGTT LVSCGDAVPG TEVEIVDPAT LTPVPAGRIG EVWLRGASIA AGYWNRPEET
     AKTFGARLAN MPGRSHLRTG DLGVLLDGGL YITGRSKDVI VIRGENHLPQ DLEHTAERAE
     PALRPSCGAA ISVDVDSVES VVLCYELASP KTEHDLDAIA ARVRQAIADR HGVETRHVVF
     VAKGGIPKTT SGKVRRQRCR ELYLNGELRV LGVVSTSRAT VPDLPDRAEI AALEPGARGP
     ALASAIGRTA AALAGAAEES PRLGEPLMRL GLDSLSAVEL RHLVQRRYGV DLGATTLADQ
     ASPDDIAAMI LAAEETGTVF EPHDVSPEHG LLPLSEGQQA LWFEHELDPH GAAYVLSRVL
     RIDGPLDVAV LGRALDALVA RHPALRTSFP VEQGRPWCRV DRTGPGLRVV DATADTDDEL
     AARLLELAER PFDLTEAPPF AATLVRRDER THLLVLAAHH LVMDLWSFLV VLDELRASYE
     AGTTPRKPVS NPHAVVLAEA TAYLQSPSHA WDRDFWHRTL AEAPPDLELP TDRPRPQHRD
     FRGATEEFRL PAELVRDLRA FARQRSCTLF TVLLTAYRAL LHRYTGQTDL VLGTLLAGRD
     SAALADAVGY FVRAVPLRSR CSGETSFDAL LADSGELLRD TTGHGRYPFR RMIAELAPER
     DADRATLVQS QFVLQQEYGE RRGGTFALAQ GSADRVGFGA ATATPVGVAR RWSQLDLSLS
     MAQLGDELTG CWEYRTALFD RTTVAGMSAH LTELLRALVT DPAQPVDAIP LRDNGTVAEA
     GPSRDWQDLG GLHRLTAEAA RTHPDVTAVV AADGTLSHSA LHRAATGIAA ELRALGALPG
     EPVAVLHERG VALPIAYLAV LHAGCAVLPL DPDDPARRHA VMLEDSGTRF LLTGNDVPGE
     EGVALPVRRL DTTALARRSG GGYSAPVHPE QPAYLLYTSG STGAPKGVLV PHRGIVNRLR
     WMQEHFRLAP GERVLHKTPV SFDVSWWELC WPLIAGGTVV LAPPGLHRDP RGLAALITRA
     AISTTHFVPS MLTPFLAEAA RLGTVASPLR RVLCSGETLP SATRDRFFEL FSAELHNLYG
     PTEASVDVTA WDCAPTEDGP VPIGLPISNT SVQVLDRRLR PVPRPIAGEL FLGGTGLATC
     YVADLAKTAA AFLPDPGGTG GRLYRTGDRA RRRPDGALVF LGRTDQQVKL GGQRVELGEV
     AEALRAQPGV TDAAAVVRDG RLIGYVCGPD APAPAELRER LRRLVPSRSV PARIVPIEAL
     PITRSGKLDH RALPVPEADP EQRTSPPRTR TERRLAELWS AHLGRSEIDV DTGFFTLGGD
     SILAIAIAAT AREAGAGFTV AELMAYPTVA SLAAHLDNRP GTAEAEDTTL APFALCPELA
     GRSGLTDAYP VSMAQRALLA HGDNDPAYEV YVTSVAVAAT LVSSALAQAV RLVLARHPYL
     RSSFDLTSQA EPVQLVWGDV PRLPLEVVDL SVHQAREERF SAWMAAERKR HFDLDHGPLV
     RFTAHDLGAG FRLTVSSFAL DGWCTALVLT EVLHAYRAAV RGETWRPVPL RTGYADFVAL
     ERAAMRSPED HAFWAAELHS AEPSTLPQRS IKPAPRPALQ QRTVLEVDDG VRDALSALGG
     ELGVGLKHVL LGVHLRVVRA LTGAEDTITG LETNGRPERR DGDRVVGVFN NILPLRVTVF
     SDASWADLAR SAYAAEGRIS PHRRYPLVAL NREFGAGALF DTLFVFTHFH LYREVSTVDG
     LRISDLQAPD QTYVPLTAHF NIDAGSGRLR LLLEADPAKV PAEQVQEVGK LFVTALEAAA
     RRPHGASSDW EGKTRTPVEA APEPAPELAV HELVEAAVRR GPARTALVEG RKHLSYRGLW
     TASAKLAEAL QAFSVGPDTV VGLWAERSVD YVVALLAVLR AGAAHLSIDP ETPPERVAAV
     LAEAGAALVV LPEGVSVPEG VAPEAVLRTS ATSGSGLRRP RLRGTNLVCV LATSGSTGQP
     KLVGVHHQGL VNYLRWCAPA YGITEKTFAP VHSSPAFDLT VTSLLAPLTA GGTAHLLPGT
     DVTNLSTALA GGHHTLVKIT PSHLVAVAGH LSARRRVLSG LTVVVGGEQL DGRQVAAARS
     VMPDALLFNE YGPTETVVGC SVHEVGVPGD GPVPIGVPIA GTSATILDAP DGPRGELAVG
     GPGVTRGYLG QPAATAAVFV PDPDRSGDRR YRTGDLVHQL PGGTLVFRGR ADRQVKLRGY
     RVDLGEIEHA LTSHPAVTGA AVVLGDTLAG TPRLIACWCG TAAVPELRDW LRRRLPARLV
     PAELRWLAAL PLTANGKVDH AALTARPERR DRLMDRIELL TDEEAARLLR MARTRPEKPG
     GSR
//